Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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growth/size/body
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• Background Sensitivity: the severe runting is less severe as the deletion is backcrossed onto the C3H background
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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mortality/aging
growth/size/body
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• in the most severe cases the face is asymmetric
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• some have misshapened palatine ridges
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• Background Sensitivity: severe growth retardation averaging only 50-80% of the weight of same-sex wildtype littermates
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craniofacial
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• Background Sensitivity: the 'Greek warrior helmet' phenotype of domed skull, small ears, and wide set eyes is found on a >50% C57BL/6J background
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• in the most severe cases the face is asymmetric and/or the jaw bones are asymmetric
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• in the most severe cases the face is asymmetric
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• some have misshapened palatine ridges
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hearing/vestibular/ear
limbs/digits/tail
skeleton
vision/eye
digestive/alimentary system
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• some have misshapened palatine ridges
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behavior/neurological
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• Morris water maze performance normal
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• froglike gait with hindlimbs splayed outward during locomotion
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• although there is a trend for increased seizure incidence, statistical significance was not found, but severity of seizure is much greater than in controls with half of the seizures in heterozygotes being maximal
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nervous system
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• although there is a trend for increased seizure incidence, statistical significance was not found, but severity of seizure is much greater than in controls with half of the seizures in heterozygotes being maximal
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• intraculminate fissure, posterior fissure, and uvular cus are lacking
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• hypoplasia of the cerebral cortex results in colliculi being more exposed
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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limbs/digits/tail
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• minor coalitions of the distal wrist bones are seen in 25% of heterozygotes, including fusions of the central to distal carpals 2 or 3
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growth/size/body
skeleton
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• minor coalitions of the distal wrist bones are seen in 25% of heterozygotes, including fusions of the central to distal carpals 2 or 3
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(5D5Mit73-D5Mit351)5Jcs mutation
(0 available);
any
Del(5D5Mit73-D5Mit351)5Jcs mutation
(0 available)
Ift172wim mutation
(0 available);
any
Ift172 mutation
(75 available)
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nervous system
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• lack the ventral midline groove in the neural plate
• markers of V3 interneurons and motor neurons were not expressed
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embryo
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• lack the ventral midline groove in the neural plate
• markers of V3 interneurons and motor neurons were not expressed
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(5D5Mit73-D5Mit351)5Jcs mutation
(0 available);
any
Del(5D5Mit73-D5Mit351)5Jcs mutation
(0 available)
Hm mutation
(3 available);
any
Hm mutation
(3 available)
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limbs/digits/tail
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• retention of skin between digits giving the appearance of webbing
• this phenotype is identical to Hm heterozygotes
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(5D5Mit73-D5Mit351)5Jcs mutation
(0 available);
any
Del(5D5Mit73-D5Mit351)5Jcs mutation
(0 available)
Lmbr1tm1Kng mutation
(0 available);
any
Lmbr1 mutation
(33 available)
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mortality/aging
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• fewer than expected mutants are present at weaning
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limbs/digits/tail
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• severe coalitions or reductions of the distal wrist bones involving distal carpal 2, 3 and/or the central as well as other distal carpals are seen in all mutants
• coalitions or reductions of the proximal wrist bones were seen in 36 out of 38 mutants
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• 55% of mutants had fewer than 5 digits with one third of these having only 3 digits
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• in forelimbs with severely affected wrists the distal ends of the radius and ulna are sometimes narrow and the junction of the radius and ulna is disorganized
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• in forelimbs with severely affected wrists the distal ends of the radius and ulna are sometimes narrow and the junction of the radius and ulna is disorganized
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growth/size/body
skeleton
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• severe coalitions or reductions of the distal wrist bones involving distal carpal 2, 3 and/or the central as well as other distal carpals are seen in all mutants
• coalitions or reductions of the proximal wrist bones were seen in 36 out of 38 mutants
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• in forelimbs with severely affected wrists the distal ends of the radius and ulna are sometimes narrow and the junction of the radius and ulna is disorganized
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• in forelimbs with severely affected wrists the distal ends of the radius and ulna are sometimes narrow and the junction of the radius and ulna is disorganized
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Analysis Tools
