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Allele Symbol Allele Name Allele ID |
Runx1tm2Buch targeted mutation 2, Frank Buchholz MGI:3798051 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• the distinction between medulla and cortex is lost in a third of the mice examined after Cre induction
• the medulla becomes populated with immature lymphoblasts
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• thymus weight is reduced to a mean of 42.0 mg before Cre induction compared to 73.9 mg in control mice
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• starting at 7 weeks post-Cre induction, there is a significant increase in spleen with a mean increase of about 40%
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• increased number of myeloid progenitors are found in the bone marrow 5 weeks after Cre-induction (34.5% vs 23.9% in controls)
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• there are increased number of myeloid progenitor cells found in the spleen but normal number of neutrophils and granulocytes in circulation
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• small megakaryocytes are found in the bone marrow after Cre induction
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• decreased megakarycote numbers are found in the bone marrow
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• Howell-Jolly bodies are present in peripheral blood smears
• more than 2 months after Cre induction, 0.51% of erythrocytes contain Howell-Jolly bodies compared of 0.16% of control mice
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• one week after Cre recombinase induction, the number of platelets in the blood is decreased by almost half
• this low number persists for at least five weeks after Cre expression
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• there is an increased fraction of HSC (11.7%) found in bone marrow 5 weeks after Cre recombinase induction compared to the 6.4% found in control mice
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• increased number of mast cells are found in the red pulp of the spleen
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• immature neutrophils make up 18.4% of splenocytes compared to 3.9% in controls
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• starting three weeks after induction of Cre recombinase, there is a significant drop in lymphocyte numbers
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• less mature B cells (15.1% of splenocytes) are found in the spleen compared to wild-type (23.6%)
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• less T cells are found in the spleen than in controls
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• there is a large decrease in the percentage of double-positive T cells found in the thymus after Cre induction (from 76.7% to 0.8%)
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• CD4 T cells in the thymus are reduced more than 4-fold
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• CD8 T cells are reduced by 2-fold in the thymus
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• immature monocytes make up 9.8% of splenocytes compared to 1.8% in controls
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• there is a striking expansion of the red bulb seven weeks after Cre-induction
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• there is a reduction and disbursement of the white pulp matter
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• one mouse had lymphoma of a cervical lymph node of the brain
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• a metastatic thymic lymphoma was found in the liver of one mouse
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• there are increased number of myeloid progenitor cells found in the spleen but normal number of neutrophils and granulocytes in circulation
|
|
• increased number of mast cells are found in the red pulp of the spleen
|
|
• immature neutrophils make up 18.4% of splenocytes compared to 3.9% in controls
|
|
• starting three weeks after induction of Cre recombinase, there is a significant drop in lymphocyte numbers
|
|
• less mature B cells (15.1% of splenocytes) are found in the spleen compared to wild-type (23.6%)
|
|
• less T cells are found in the spleen than in controls
|
|
• there is a large decrease in the percentage of double-positive T cells found in the thymus after Cre induction (from 76.7% to 0.8%)
|
|
• CD4 T cells in the thymus are reduced more than 4-fold
|
|
• CD8 T cells are reduced by 2-fold in the thymus
|
|
• immature monocytes make up 9.8% of splenocytes compared to 1.8% in controls
|
|
• the distinction between medulla and cortex is lost in a third of the mice examined after Cre induction
• the medulla becomes populated with immature lymphoblasts
|
|
• thymus weight is reduced to a mean of 42.0 mg before Cre induction compared to 73.9 mg in control mice
|
|
• starting at 7 weeks post-Cre induction, there is a significant increase in spleen with a mean increase of about 40%
|
|
• there is a striking expansion of the red bulb seven weeks after Cre-induction
|
|
• there is a reduction and disbursement of the white pulp matter
|
|
• Peyer's patches of mice after Cre induction are smaller than in controls
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• lymph nodes of mice after Cre induction are smaller than in controls
|
|
• the distinction between medulla and cortex is lost in a third of the mice examined after Cre induction
• the medulla becomes populated with immature lymphoblasts
|
|
• thymus weight is reduced to a mean of 42.0 mg before Cre induction compared to 73.9 mg in control mice
|
|
• a metastatic thymic lymphoma was found in the liver of one mouse
|
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• starting at 7 weeks post-Cre induction, there is a significant increase in spleen with a mean increase of about 40%
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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