Phenotypes associated with this allele

• Allele Symbol: Neurog3^{tm1.1(cre/ERT)Ggu}
• Allele Name: targeted mutation 1.1, Guoqiang Gu
• Allele ID: MGI:3796207
• Summary: 5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Neurog3^tm1.1(cre/ERT)Ggu/Neurog3^+	involves: 129S6/SvEvTac	MGI:3850074
cn2	Neurog3^tm1(Neurog3,cre/ERT)Ggu/Neurog3^tm1.1(cre/ERT)Ggu	involves: 129S6/SvEvTac	MGI:3850073
cn3	Neurog3^tm1.1(cre/ERT)Ggu/Neurog3^+ Pdx1^tm1Macd/Pdx1^+ Tg(tetO-Myt1)2Ggu/0	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ	MGI:3809541
cn4	Neurog3^tm1(Neurog3,cre/ERT)Ggu/Neurog3^tm1.1(cre/ERT)Ggu Tg(Pdx1-cre/Esr1*)1Mga/0	involves: 129S6/SvEvTac	MGI:3850077
cn5	Neurog3^tm1(Neurog3,cre/ERT)Ggu/Neurog3^tm1.1(cre/ERT)Ggu Tg(Ins2-cre)25Mgn/0	involves: 129S6/SvEvTac * C57BL/6 * DBA	MGI:3850075

Genotype
MGI:3850074

ht1

• Allelic Composition: Neurog3^{tm1.1(cre/ERT)Ggu}/Neurog3⁺
• Genetic Background: involves: 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

impaired glucose tolerance ( J:150074 )

Genotype
MGI:3850073

cn2

• Allelic Composition: Neurog3^{tm1(Neurog3,cre/ERT)Ggu}/Neurog3^{tm1.1(cre/ERT)Ggu}
• Genetic Background: involves: 129S6/SvEvTac

homeostasis/metabolism

impaired glucose tolerance ( J:150074 )

Genotype
MGI:3809541

cn3

• Allelic Composition: Neurog3^{tm1.1(cre/ERT)Ggu}/Neurog3⁺; Pdx1^tm1Macd/Pdx1⁺; Tg(tetO-Myt1)2Ggu/0
• Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ

endocrine/exocrine glands

abnormal pancreatic islet morphology ( J:136131 )

• fewer cells are induced to produce glucagons than in Pdx1^tm1Macd/Pdx1⁺ Tg(tetO-Neurog3)8Ggu mice

Genotype
MGI:3850077

cn4

• Allelic Composition: Neurog3^{tm1(Neurog3,cre/ERT)Ggu}/Neurog3^{tm1.1(cre/ERT)Ggu}; Tg(Pdx1-cre/Esr1*)1Mga/0
• Genetic Background: involves: 129S6/SvEvTac

homeostasis/metabolism

increased circulating glucose level ( J:150074 )

• in male mice 4 weeks after tamoxifen treatment

hyperglycemia ( J:150074 )

• in male mice 12 weeks after tamoxifen treatment

abnormal circulating insulin level ( J:150074 )

• 12 weeks after tamoxifen treatment, postglucose-challenge-serum-insulin levels are decreased unlike in similarly treated wild-type mice

impaired glucose tolerance ( J:150074 )

• in female mice 2 and 3 months after tamoxifen treatment and in male mice 12 weeks after tamoxifen treatment

Genotype
MGI:3850075

cn5

• Allelic Composition: Neurog3^{tm1(Neurog3,cre/ERT)Ggu}/Neurog3^{tm1.1(cre/ERT)Ggu}; Tg(Ins2-cre)25Mgn/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA

homeostasis/metabolism

increased circulating glucose level ( J:150074 )

• at 6 weeks compared to in Neurog3^{tm1(cre/ESR1)Ggu}/Neurog3^{tm1.1(cre/ESR1)Ggu} mice