Pdx1^tm1Macd
Targeted Allele Detail

Summary

• Symbol: Pdx1^tm1Macd
• Name: pancreatic and duodenal homeobox 1; targeted mutation 1, Raymond J MacDonald
• MGI ID: MGI:2388676
• Synonyms: Pdx1^tTA
• Gene: Pdx1 Location: Chr5:147206907-147212658 bp, + strand Genetic Position: Chr5, 86.84 cM
• Alliance: Pdx1^tm1Macd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:79206
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Transactivator)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1 and 2, which encompass the entire coding region, were replaced with a cassette containing a tetracycline transactivator (tTA) and a neo resistance gene. RT-PCR showed tTA expression in adult pancreas tissue but not in other visceral organs or salivary glands. (J:79206)

Expression

In Mice Carrying this Mutation:

9 assay results

Tumor Data

List all tumor models in MMHCdb carrying Pdx1^tm1Macd

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pdx1 Mutation: 35 strains or lines available

References

• Original: J:79206 Holland AM, et al., Experimental control of pancreatic development and maintenance. Proc Natl Acad Sci U S A. 2002 Sep 17;99(19):12236-41
• All: 26 reference(s)