Neurog3^{tm1(Neurog3,cre/ERT)Ggu}
Targeted Allele Detail

Summary

• Symbol: Neurog3^{tm1(Neurog3,cre/ERT)Ggu}
• Name: neurogenin 3; targeted mutation 1, Guoqiang Gu
• MGI ID: MGI:3796205
• Synonyms: Neurog3^FLOX, Neurog3^{tm1(cre/ERT)Ggu}, Neurog3^{tm1(cre/ESR1)Ggu}, Ngn3^F
• Gene: Neurog3 Location: Chr10:61968869-61970542 bp, + strand Genetic Position: Chr10, 32.35 cM, cytoband B4
• Alliance: Neurog3^{tm1(Neurog3,cre/ERT)Ggu} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:136131
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Neurog3^{tm1(Neurog3,cre/ERT)Ggu} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Neurog3 (MGI:893591)

• Mutation details: A cassette containing a floxed version of the open reading frame followed by a cre/ERT fusion gene was inserted to replace the endogenous gene. This allele expresses a normal Neurog3 protein unless exposed to Cre recombinase, which then causes recombination of the loxP sites and expression of the cre/ERT fusion. (J:136131)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Neurog3 (mouse) Summary of all recombinase alleles driven by Neurog3. Alliance mouse Neurog3 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Neurog3 Mutation: 18 strains or lines available

References

• Original: J:136131 Wang S, et al., Myt1 and Ngn3 form a feed-forward expression loop to promote endocrine islet cell differentiation. Dev Biol. 2008 May 15;317(2):531-40
• All: 5 reference(s)