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Allele Symbol Allele Name Allele ID |
Alox12btm1.1Krie targeted mutation 1.1, Peter Krieg MGI:3795936 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• more tightly packed than in wild-type mice
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• vacuole-like structures in the granular layers of neonates
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• mice lack ester-bound ceramides in the epidermis compared with wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Impaired epidermal barrier in Alox12btm1.1Krie/Alox12btm1.1Krie mice
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• all homozygous mutant mice died within 3-5 h after birth
• no embryonic lethality and at birth homozygous mice were hard to distinguish from wild-type
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• homozygous neonates did not feed and became progressively dehydrated prior to death within 3-5 h after birth
• about 30 % of their body weight was lost within 3 h by increased transepidermal water loss
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• skin of mutant mice remained permeable at E18.5
• the barrier function of tight junctions were not affected
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• skin of mutant mice remained permeable at E18.5
• the barrier function of tight junctions were not affected
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• the stratum corneum is more tightly packed than in wild-type
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• numerous vacuole-like structure were observed in the upper granular layers
• EM confirmed vesicular structures of variable sizes in granular layer cells
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• an increased fragility of the mutant cornified envelope
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/07/2024 MGI 6.23 |
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