Alox12btm1.1Krie
Targeted Allele Detail
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Symbol: |
Alox12btm1.1Krie |
Name: |
arachidonate 12-lipoxygenase, 12R type; targeted mutation 1.1, Peter Krieg |
MGI ID: |
MGI:3795936 |
Gene: |
Alox12b Location: Chr11:69047898-69060617 bp, + strand Genetic Position: Chr11, 42.38 cM
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Alliance: |
Alox12btm1.1Krie page
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Impaired epidermal barrier in Alox12btm1.1Krie/Alox12btm1.1Krie mice
Show the 4 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:134709
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Parent Cell Line: |
E14 (ES Cell)
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Strain of Origin: |
129P2/OlaHsd
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Allele Type: |
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Targeted (Null/knockout) |
Mutation: |
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Intragenic deletion
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Mutation details: Heterozygous Alox12btm1Krie mice was crossed with deleter mice expressing Cre recombinase resulting in excision of the tk/neo selection cassette and exon 8. The mutated RNA expression was confirmed by RT-PCR, however, no protein product was detected by Western blot.
(J:134709)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Alox12b Mutation: |
38 strains or lines available
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Original: |
J:134709 Epp N, et al., 12R-lipoxygenase deficiency disrupts epidermal barrier function. J Cell Biol. 2007 Apr 9;177(1):173-82 |
All: |
3 reference(s) |
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