Phenotypes associated with this allele

• Allele Symbol: Msx2^tm1Yvla
• Allele Name: targeted mutation 1, Yvan Lallemand
• Allele ID: MGI:3795774
• Summary: 7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Msx2^tm1Yvla/Msx2^tm1Yvla	involves: 129S2/SvPas * C57BL/6 * SJL	MGI:3797242
cn2	Msx1^tm1Bero/Msx1^tm1Bero Msx2^tm1Bero/Msx2^tm1Yvla Tagln^tm2(cre)Yec/Tagln^+	involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac * NMRI	MGI:5297709
cn3	Msx1^tm1Bero/Msx1^tm2.1(cre/ERT2)Bero Msx2^tm1Yvla/Msx2^tm1Yvla	involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6 * NMRI	MGI:5297713
cn4	Msx1^tm1Rem/Msx1^tm1Rem Msx2^tm1Yvla/Msx2^tm1Yvla Tg(Tek-cre)1Ywa/0	involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6 * NMRI * SJL	MGI:5297712
cn5	Msx1^tm1Rem/Msx1^tm1Rem Msx2^tm1Yvla/Msx2^tm1Yvla Tagln^tm2(cre)Yec/Tagln^+	involves: 129S2/SvPas * 129S6/SvEvTac * NMRI	MGI:5297710
cx6	Msx1^tm1Bero/Msx1^tm1Bero Msx2^tm1Yvla/Msx2^tm1Yvla	involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6 * SJL	MGI:3797244
cx7	Msx1^tm1Bero/Msx1^tm1Bero Msx2^tm1Bero/Msx2^tm1Yvla	involves: 129/Sv * BALB/c * C57BL/6 * SJL	MGI:3797245

Genotype
MGI:3797242

hm1

• Allelic Composition: Msx2^tm1Yvla/Msx2^tm1Yvla
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:136241 )

• mice are indistinguishable form wild-type mice

Genotype
MGI:5297709

cn2

• Allelic Composition: Msx1^tm1Bero/Msx1^tm1Bero; Msx2^tm1Bero/Msx2^tm1Yvla; Tagln^tm2(cre)Yec/Tagln⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac * NMRI

cardiovascular system

abnormal artery morphology ( J:173525 )

• superficial temporal artery is more branched than in controls

abnormal carotid artery morphology ( J:173525 )

• at E11.5, carotid artery (CA) overbranching is observed

abnormal vertebral artery morphology ( J:173525 )

• vertebral artery (VA) caliber is increased relative to controls

vascular smooth muscle hypoplasia ( J:173525 )

• number of smooth muscle actin-positive cells in CA is half that observed in controls

intracranial aneurysm ( J:173525 )

• in the head, aneurysms are frequently observed

intracranial hemorrhage ( J:173525 )

• in the head, hemorrhages are frequently observed

muscle

vascular smooth muscle hypoplasia ( J:173525 )

• number of smooth muscle actin-positive cells in CA is half that observed in controls

nervous system

intracranial hemorrhage ( J:173525 )

• in the head, hemorrhages are frequently observed

Genotype
MGI:5297713

cn3

• Allelic Composition: Msx1^tm1Bero/Msx1^{tm2.1(cre/ERT2)Bero}; Msx2^tm1Yvla/Msx2^tm1Yvla
• Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6 * NMRI

cardiovascular system

abnormal carotid artery morphology ( J:173525 )

• increased carotid artery vessel diameter is observed

vascular smooth muscle hypoplasia ( J:173525 )

• a reduction in vascular smooth muscle cell (VSMC) coverage (depletion of mural cells) is observed

muscle

vascular smooth muscle hypoplasia ( J:173525 )

• a reduction in vascular smooth muscle cell (VSMC) coverage (depletion of mural cells) is observed

Genotype
MGI:5297712

cn4

• Allelic Composition: Msx1^tm1Rem/Msx1^tm1Rem; Msx2^tm1Yvla/Msx2^tm1Yvla; Tg(Tek-cre)1Ywa/0
• Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6 * NMRI * SJL

cardiovascular system

cardiovascular system phenotype ( J:173525 )

N • carotid artery diamter and vascular smooth muscle cell (VSMC) are observed

Genotype
MGI:5297710

cn5

• Allelic Composition: Msx1^tm1Rem/Msx1^tm1Rem; Msx2^tm1Yvla/Msx2^tm1Yvla; Tagln^tm2(cre)Yec/Tagln⁺
• Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * NMRI

cardiovascular system

abnormal carotid artery morphology ( J:173525 )

• increased carotid artery section surface (increased vessel diameter) is observed

vascular smooth muscle hypoplasia ( J:173525 )

• a reduction in vascular smooth muscle cell (VSMC) coverage (depletion of mural cells) is observed

muscle

vascular smooth muscle hypoplasia ( J:173525 )

• a reduction in vascular smooth muscle cell (VSMC) coverage (depletion of mural cells) is observed

Genotype
MGI:3797244

cx6

• Allelic Composition: Msx1^tm1Bero/Msx1^tm1Bero; Msx2^tm1Yvla/Msx2^tm1Yvla
• Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6 * SJL

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:136241 )

• mice do not survive beyond E14.5

craniofacial

abnormal craniofacial morphology ( J:136241 )

• mice exhibit craniofacial malformations

limbs/digits/tail

abnormal limb development ( J:136241 )

• mice exhibit limb malformations

nervous system

exencephaly ( J:136241 )

growth/size/body

thoracoabdominoschisis ( J:136241 )

• thoracoabdominoschisis

Genotype
MGI:3797245

cx7

• Allelic Composition: Msx1^tm1Bero/Msx1^tm1Bero; Msx2^tm1Bero/Msx2^tm1Yvla
• Genetic Background: involves: 129/Sv * BALB/c * C57BL/6 * SJL

mortality/aging

perinatal lethality ( J:136241 )

craniofacial

abnormal craniofacial development ( J:136241 )

cleft palate ( J:136241 )

short snout ( J:136241 )

digestive/alimentary system

cleft palate ( J:136241 )

growth/size/body

cleft palate ( J:136241 )

short snout ( J:136241 )