All Phenotypes Msx2<tm1Yvla> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Msx2^tm1Yvla
targeted mutation 1, Yvan Lallemand
MGI:3795774

Summary

7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Msx2^tm1Yvla/Msx2^tm1Yvla	involves: 129S2/SvPas * C57BL/6 * SJL	MGI:3797242
cn2	Msx1^tm1Bero/Msx1^tm1Bero Msx2^tm1Bero/Msx2^tm1Yvla Tagln^tm2(cre)Yec/Tagln⁺	involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac * NMRI	MGI:5297709
cn3	Msx1^tm1Bero/Msx1^{tm2.1(cre/ERT2)Bero} Msx2^tm1Yvla/Msx2^tm1Yvla	involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6 * NMRI	MGI:5297713
cn4	Msx1^tm1Rem/Msx1^tm1Rem Msx2^tm1Yvla/Msx2^tm1Yvla Tg(Tek-cre)1Ywa/0	involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6 * NMRI * SJL	MGI:5297712
cn5	Msx1^tm1Rem/Msx1^tm1Rem Msx2^tm1Yvla/Msx2^tm1Yvla Tagln^tm2(cre)Yec/Tagln⁺	involves: 129S2/SvPas * 129S6/SvEvTac * NMRI	MGI:5297710
cx6	Msx1^tm1Bero/Msx1^tm1Bero Msx2^tm1Yvla/Msx2^tm1Yvla	involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6 * SJL	MGI:3797244
cx7	Msx1^tm1Bero/Msx1^tm1Bero Msx2^tm1Bero/Msx2^tm1Yvla	involves: 129/Sv * BALB/c * C57BL/6 * SJL	MGI:3797245

Allelic Composition	Msx2^tm1Yvla/Msx2^tm1Yvla
Genetic Background	involves: 129S2/SvPas * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msx2^tm1Yvla mutation (0 available); any Msx2 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:136241 )

• mice are indistinguishable form wild-type mice

Allelic Composition	Msx1^tm1Bero/Msx1^tm1Bero Msx2^tm1Bero/Msx2^tm1Yvla Tagln^tm2(cre)Yec/Tagln⁺
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac * NMRI

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msx1^tm1Bero mutation (1 available); any Msx1 mutation (18 available)
Msx2^tm1Bero mutation (1 available); any Msx2 mutation (23 available)
Msx2^tm1Yvla mutation (0 available); any Msx2 mutation (23 available)
Tagln^tm2(cre)Yec mutation (1 available); any Tagln mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal artery morphology ( J:173525 )

• superficial temporal artery is more branched than in controls

abnormal carotid artery morphology ( J:173525 )

• at E11.5, carotid artery (CA) overbranching is observed

abnormal vertebral artery morphology ( J:173525 )

• vertebral artery (VA) caliber is increased relative to controls

vascular smooth muscle hypoplasia ( J:173525 )

• number of smooth muscle actin-positive cells in CA is half that observed in controls

intracranial aneurysm ( J:173525 )

• in the head, aneurysms are frequently observed

intracranial hemorrhage ( J:173525 )

• in the head, hemorrhages are frequently observed

muscle

vascular smooth muscle hypoplasia ( J:173525 )

• number of smooth muscle actin-positive cells in CA is half that observed in controls

nervous system

intracranial hemorrhage ( J:173525 )

• in the head, hemorrhages are frequently observed

Allelic Composition	Msx1^tm1Bero/Msx1^{tm2.1(cre/ERT2)Bero} Msx2^tm1Yvla/Msx2^tm1Yvla
Genetic Background	involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6 * NMRI

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msx1^tm1Bero mutation (1 available); any Msx1 mutation (18 available)
Msx1^{tm2.1(cre/ERT2)Bero} mutation (2 available); any Msx1 mutation (18 available)
Msx2^tm1Yvla mutation (0 available); any Msx2 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal carotid artery morphology ( J:173525 )

• increased carotid artery vessel diameter is observed

vascular smooth muscle hypoplasia ( J:173525 )

• a reduction in vascular smooth muscle cell (VSMC) coverage (depletion of mural cells) is observed

muscle

vascular smooth muscle hypoplasia ( J:173525 )

• a reduction in vascular smooth muscle cell (VSMC) coverage (depletion of mural cells) is observed

Allelic Composition	Msx1^tm1Rem/Msx1^tm1Rem Msx2^tm1Yvla/Msx2^tm1Yvla Tg(Tek-cre)1Ywa/0
Genetic Background	involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6 * NMRI * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msx1^tm1Rem mutation (1 available); any Msx1 mutation (18 available)
Msx2^tm1Yvla mutation (0 available); any Msx2 mutation (23 available)
Tg(Tek-cre)1Ywa mutation (6 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:173525 )

N	• carotid artery diamter and vascular smooth muscle cell (VSMC) are observed

Allelic Composition	Msx1^tm1Rem/Msx1^tm1Rem Msx2^tm1Yvla/Msx2^tm1Yvla Tagln^tm2(cre)Yec/Tagln⁺
Genetic Background	involves: 129S2/SvPas * 129S6/SvEvTac * NMRI

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal carotid artery morphology ( J:173525 )

• increased carotid artery section surface (increased vessel diameter) is observed

vascular smooth muscle hypoplasia ( J:173525 )

• a reduction in vascular smooth muscle cell (VSMC) coverage (depletion of mural cells) is observed

muscle

vascular smooth muscle hypoplasia ( J:173525 )

• a reduction in vascular smooth muscle cell (VSMC) coverage (depletion of mural cells) is observed

Allelic Composition	Msx1^tm1Bero/Msx1^tm1Bero Msx2^tm1Yvla/Msx2^tm1Yvla
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msx1^tm1Bero mutation (1 available); any Msx1 mutation (18 available)
Msx2^tm1Yvla mutation (0 available); any Msx2 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:136241 )

• mice do not survive beyond E14.5

craniofacial

abnormal craniofacial morphology ( J:136241 )

• mice exhibit craniofacial malformations

limbs/digits/tail

abnormal limb development ( J:136241 )

• mice exhibit limb malformations

nervous system

exencephaly ( J:136241 )

growth/size/body

thoracoabdominoschisis ( J:136241 )

• thoracoabdominoschisis

Allelic Composition	Msx1^tm1Bero/Msx1^tm1Bero Msx2^tm1Bero/Msx2^tm1Yvla
Genetic Background	involves: 129/Sv * BALB/c * C57BL/6 * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality ( J:136241 )

craniofacial

abnormal craniofacial development ( J:136241 )

cleft palate ( J:136241 )

short snout ( J:136241 )

digestive/alimentary system

cleft palate ( J:136241 )

growth/size/body

cleft palate ( J:136241 )

short snout ( J:136241 )

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