Phenotypes associated with this allele

• Allele Symbol: Nr5a2^tm1Sakl
• Allele Name: targeted mutation 1, Steven A Kliewer
• Allele ID: MGI:3795276
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Nr5a2^tm1Sakl/Nr5a2^tm1Sakl Speer6-ps1^Tg(Alb-cre)21Mgn/Speer6-ps1^+	involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * DBA	MGI:3797770
cn2	Nr5a2^tm1Sakl/Nr5a2^tm1Sakl Tg(Vil1-cre)997Gum/0	involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6J * SJL	MGI:3797771

Genotype
MGI:3797770

cn1

• Allelic Composition: Nr5a2^tm1Sakl/Nr5a2^tm1Sakl; Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺
• Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * DBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased circulating cholesterol level ( J:135822 )

decreased circulating aspartate transaminase level ( J:135822 )

liver/biliary system

abnormal bile composition ( J:135822 )

• bile contains higher concentrations of tauromuricholic acids, taurochenodeoxycholic acid, alpha/omega muricholic acid, and beta-muricholic acid and lower concentrations of taurocholic acid and taurodeoxycholic acid compared to bile in wild-type mice

endocrine/exocrine glands

abnormal bile composition ( J:135822 )

• bile contains higher concentrations of tauromuricholic acids, taurochenodeoxycholic acid, alpha/omega muricholic acid, and beta-muricholic acid and lower concentrations of taurocholic acid and taurodeoxycholic acid compared to bile in wild-type mice

Genotype
MGI:3797771

cn2

• Allelic Composition: Nr5a2^tm1Sakl/Nr5a2^tm1Sakl; Tg(Vil1-cre)997Gum/0
• Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6J * SJL

homeostasis/metabolism

decreased circulating cholesterol level ( J:135822 )

decreased circulating aspartate transaminase level ( J:135822 )

digestive/alimentary system

digestive/alimentary phenotype ( J:135822 )

N • unlike heterozygous null mice, villus length, crypt depth and intestinal proliferation are normal