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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nr5a2tm1Sakl
targeted mutation 1, Steven A Kliewer
MGI:3795276
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Nr5a2tm1Sakl/Nr5a2tm1Sakl
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ 		involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * DBA MGI:3797770
cn2
 		Nr5a2tm1Sakl/Nr5a2tm1Sakl
Tg(Vil1-cre)997Gum/0 		involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6J * SJL MGI:3797771


Genotype
MGI:3797770
cn1
Allelic
Composition		 Nr5a2tm1Sakl/Nr5a2tm1Sakl
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic
Background		 involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr5a2tm1Sakl mutation (1 available); any Nr5a2 mutation (94 available)
Speer6-ps1Tg(Alb-cre)21Mgn mutation (6 available); any Speer6-ps1 mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism

liver/biliary system
abnormal bile composition ( J:135822 )
• bile contains higher concentrations of tauromuricholic acids, taurochenodeoxycholic acid, alpha/omega muricholic acid, and beta-muricholic acid and lower concentrations of taurocholic acid and taurodeoxycholic acid compared to bile in wild-type mice




Genotype
MGI:3797771
cn2
Allelic
Composition		 Nr5a2tm1Sakl/Nr5a2tm1Sakl
Tg(Vil1-cre)997Gum/0
Genetic
Background		 involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr5a2tm1Sakl mutation (1 available); any Nr5a2 mutation (94 available)
Tg(Vil1-cre)997Gum mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism

digestive/alimentary system
digestive/alimentary phenotype ( J:135822 )
N
• unlike heterozygous null mice, villus length, crypt depth and intestinal proliferation are normal




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory