Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc1tm1.1Tyj mutation
(1 available);
any
Mirc1 mutation
(6 available)
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normal phenotype
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• viable with no obvious abnormalities
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc1tm1.1Tyj mutation
(1 available);
any
Mirc1 mutation
(6 available)
Pkd1tm1.1Pcha mutation
(0 available);
any
Pkd1 mutation
(153 available)
Pkd1tm2Som mutation
(0 available);
any
Pkd1 mutation
(153 available)
Tg(Cdh16-cre)91Igr mutation
(1 available)
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renal/urinary system
N |
• renal function and renal interstitial fibrosis are improved compared to conditional Pkd1 compound heterozygotes and mice live past 1 year of age
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• mice show a decrease in cyst epithelial cell proliferation compared to conditional Pkd1 compound heterozygotes
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• cyst size is reduced compared to conditional Pkd1 compound heterozygotes
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• kidney weight is reduced compared to conditional Pkd1 compound heterozygotes
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cellular
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• the number of peroxisomes in the kidneys is reduced compared to conditional Pkd1 compound heterozygotes
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• mice show a decrease in cyst epithelial cell proliferation compared to conditional Pkd1 compound heterozygotes
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• fatty acid oxidation is increased in kidneys compared to conditional Pkd1 compound heterozygotes
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• reactive oxidative species level is decreased in the kidneys compared to conditional Pkd1 compound heterozygotes
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homeostasis/metabolism
growth/size/body
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• cyst size is reduced compared to conditional Pkd1 compound heterozygotes
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc1tm1.1Tyj mutation
(1 available);
any
Mirc1 mutation
(6 available)
Pkd1tm1.1Pcha mutation
(0 available);
any
Pkd1 mutation
(153 available)
Tg(Cdh16-cre)91Igr mutation
(1 available)
|
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renal/urinary system
N |
• mice exhibit attenuated cyst growth and reduced renal fibrosis compared to single Pkd1tm1.1Pcha homozygotes
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homeostasis/metabolism
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc1tm1.1Tyj mutation
(1 available);
any
Mirc1 mutation
(6 available)
Pkd2tm3Som mutation
(0 available);
any
Pkd2 mutation
(84 available)
Tg(Pkhd1-cre)1Igr mutation
(0 available)
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mortality/aging
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• mice have a median survival of 127 days which is 149% increase in median survival compared to single conditional Pkd2 mutants
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renal/urinary system
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• mice show a 58.9% decrease in the number of proliferating cyst epithelial cells compared to single conditional Pkd2 mutants
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• mice show a 15.8% reduction in cyst index compared to single conditional Pkd2 mutants
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cellular
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• mice show a 58.9% decrease in the number of proliferating cyst epithelial cells compared to single conditional Pkd2 mutants
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homeostasis/metabolism
growth/size/body
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• mice show a 15.8% reduction in cyst index compared to single conditional Pkd2 mutants
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mirc1tm1.1Tyj mutation
(1 available);
any
Mirc1 mutation
(6 available)
Pkd1tm2Som mutation
(0 available);
any
Pkd1 mutation
(153 available)
Tg(Cdh16-cre)91Igr mutation
(1 available)
|
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mortality/aging
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• mice exhibit a median survival of 21 days which is a 50% improvement compared to single Pkd1 conditional mutants
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renal/urinary system
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• the number of proliferating cyst epithelial cells is reduced by 78.7% compared to single Pkd1 conditional mutants
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• mice exhibit a 26.8% reduction in kidney-weight-to-body-weight ratio compared to single Pkd1 conditional mutants
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cellular
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• the number of proliferating cyst epithelial cells is reduced by 78.7% compared to single Pkd1 conditional mutants
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homeostasis/metabolism