Mirc1^tm1.1Tyj
Targeted Allele Detail

Summary

• Symbol: Mirc1^tm1.1Tyj
• Name: microRNA cluster 1, including Mir17 through Mir92-1; targeted mutation 1.1, Tyler Jacks
• MGI ID: MGI:3793628
• Synonyms: miR17~92^fl, Mir17-92^tm1.1Tyj
• Gene: Mirc1 Location: Chr14:115281103-115281938 bp Genetic Position: Chr14, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:134861
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The Frt-flanked neomycin cassette in Mir17-92^tm1Tyj was removed through Flp-mediated excision. (J:134861)

Expression

In Mice Carrying this Mutation:

260094 assay results 7 RNA-Seq or microarray experiment(s)

Tumor Data

List all tumor models in MMHCdb carrying Mirc1^tm1.1Tyj

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mirc1 Mutation: 6 strains or lines available

References

• Original: J:134861 Ventura A, et al., Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters. Cell. 2008 Mar 7;132(5):875-86
• All: 59 reference(s)