Phenotypes associated with this allele

• Allele Symbol: Foxd3^tm3Lby
• Allele Name: targeted mutation 3, Patricia A Labosky
• Allele ID: MGI:3790794
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Foxd3^tm2Lby/Foxd3^tm3Lby H2az2^Tg(Wnt1-cre)11Rth/H2az2^+	involves: 129S6/SvEvTac * C57BL/6 * CBA	MGI:3806465

Genotype
MGI:3806465

cn1

• Allelic Composition: Foxd3^tm2Lby/Foxd3^tm3Lby; H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:134482 )

• live embryos were found in the expected ratios at all times in development but no mutant mice survived more than a few hours

craniofacial

abnormal cranium morphology ( J:134482 )

• cranial defects are observed at midgestation stages

small basioccipital bone ( J:134482 )

• the basioccipital bone is present but smaller in size

absent frontal bone ( J:134482 )

• the frontal bone is missing

small interparietal bone ( J:134482 )

• the interparietal bone is greatly reduced in size

small parietal bone ( J:134482 )

• the parietal bone is greatly reduced in size

mandibular hyperostosis ( J:134482 )

• the mandible is thickened

short mandible ( J:134482 )

• the mandible is shortened

short premaxilla ( J:134482 )

short maxilla ( J:134482 )

absent nasal capsule ( J:134482 )

• the nasal capsule is missing

small pharyngeal arch ( J:134482 )

• reduced in size and striking decrease of neural crest cells

cleft palate ( J:134482 )

• all mutant mice had a severe cleft face and palate incompatible with survival

midline facial cleft ( J:134482 )

• the facial midline never fused

digestive/alimentary system

cleft palate ( J:134482 )

• all mutant mice had a severe cleft face and palate incompatible with survival

respiratory system

absent nasal capsule ( J:134482 )

• the nasal capsule is missing

respiratory failure ( J:134482 )

• due to severe cleft face and palate, mutant mice were unable to breathe after birth

vision/eye

eyelids open at birth ( J:134482 )

• the eyelids were partially open at birth

skeleton

abnormal cranium morphology ( J:134482 )

• cranial defects are observed at midgestation stages

small basioccipital bone ( J:134482 )

• the basioccipital bone is present but smaller in size

absent frontal bone ( J:134482 )

• the frontal bone is missing

small interparietal bone ( J:134482 )

• the interparietal bone is greatly reduced in size

small parietal bone ( J:134482 )

• the parietal bone is greatly reduced in size

mandibular hyperostosis ( J:134482 )

• the mandible is thickened

short mandible ( J:134482 )

• the mandible is shortened

short premaxilla ( J:134482 )

short maxilla ( J:134482 )

absent nasal capsule ( J:134482 )

• the nasal capsule is missing

embryo

abnormal cardiac neural crest cell migration ( J:134482 )

• fewer neural crest cells entering the heart field

abnormal enteric neural crest cell migration ( J:134482 )

• no mutant neural crest cells entered the developing gut

small pharyngeal arch ( J:134482 )

• reduced in size and striking decrease of neural crest cells

nervous system

increased hindbrain apoptosis ( J:134482 )

abnormal enteric nervous system morphology ( J:134482 )

• the neurons and glia in enteric nerves system derived from neural crest cell are absent

small dorsal root ganglion ( J:134482 )

abnormal spinal nerve morphology ( J:134482 )

• spinal nerves along the trunk of the mutant embryos were thinner

abnormal dorsal spinal root morphology ( J:134482 )

• spinal nerves exiting the dorsal root ganglia are absent

cardiovascular system

abnormal common carotid artery morphology ( J:134482 )

• a duplication of the left common carotid artery

persistent truncus arteriosus ( J:134482 )

abnormal heart development ( J:134482 )

• fewer neural crest cells entering the heart field

cellular

increased apoptosis ( J:134482 )

• increased apoptotic cells in the dorsal spinal cord, in the hindbrain, and in the posterior tail

increased hindbrain apoptosis ( J:134482 )

abnormal cardiac neural crest cell migration ( J:134482 )

• fewer neural crest cells entering the heart field

abnormal enteric neural crest cell migration ( J:134482 )

• no mutant neural crest cells entered the developing gut

growth/size/body

absent nasal capsule ( J:134482 )

• the nasal capsule is missing

cleft palate ( J:134482 )

• all mutant mice had a severe cleft face and palate incompatible with survival

midline facial cleft ( J:134482 )

• the facial midline never fused