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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cmklr1tm1Drg
targeted mutation 1, David R Greaves
MGI:3785491
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cmklr1tm1Drg/Cmklr1tm1Drg Not Specified MGI:3796052


Genotype
MGI:3796052
hm1
Allelic
Composition		 Cmklr1tm1Drg/Cmklr1tm1Drg
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cmklr1tm1Drg mutation (0 available); any Cmklr1 mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
impaired macrophage chemotaxis ( J:133968 )
• peritoneal macrophages lack chemotatic activity towards chemerin or a chemerin-derived peptide but will migrate towards other chemoattractants such as RANTES
impaired neutrophil recruitment ( J:133968 )
• administration of a chemerin-derived peptide that lacks chemoattractant activity is unable to surpress recruitment of neutrophils to the peritoneum upon zymosan administration

cellular
impaired macrophage chemotaxis ( J:133968 )
• peritoneal macrophages lack chemotatic activity towards chemerin or a chemerin-derived peptide but will migrate towards other chemoattractants such as RANTES

hematopoietic system
impaired macrophage chemotaxis ( J:133968 )
• peritoneal macrophages lack chemotatic activity towards chemerin or a chemerin-derived peptide but will migrate towards other chemoattractants such as RANTES
impaired neutrophil recruitment ( J:133968 )
• administration of a chemerin-derived peptide that lacks chemoattractant activity is unable to surpress recruitment of neutrophils to the peritoneum upon zymosan administration




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory