Analysis Tools
cardiovascular system
| N |
• mice show normal distributions of ribosomes in cardiomyocytes
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Allele Symbol Allele Name Allele ID |
Tg(Myh6-cre)1Jmk transgene insertion 1, Jeffery D Molkentin MGI:3779100 |
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| Summary |
5 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice show normal distributions of ribosomes in cardiomyocytes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 30% of cells having Gata4 expression are larger than Gata4-deficient cells in the heart
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• heart displays dilation, but this is less prominent than if deletion is produced by Tg(Myh7-cre)1Jmk
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• significant reduction of fractional shortening is observed at 24 weeks
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• 30% of cells having Gata4 expression are larger than Gata4-deficient cells in the heart
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• significant reduction of fractional shortening is observed at 24 weeks
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• following transverse aortic constriction (TAC), severe pulmonary edema is observed
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• following transverse aortic constriction (TAC), severe pulmonary edema is observed
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Kdm4atm1Zpl/Kdm4atm1Zpl Tg(Myh6-cre)1Jmk/0 mice exhibit abnormal heart phenotypes following transverse aortic constriction
| N |
• mice exhibit normal baseline cardiac phenotype
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• following transverse aortic constriction
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• following transverse aortic constriction
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• following transverse aortic constriction, mice exhibit decreased left ventricular internal dimension in systole compared with wild-type mice
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• following transverse aortic constriction
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• following transverse aortic constriction, mice exhibit a smaller increase in heart weight to body weight and cross-sectional cardiomyocyte areas and improved cardiac function compared with similarly treated wild-type mice
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• following transverse aortic constriction, mice exhibit a smaller increase in heart weight to body weight and cross-sectional cardiomyocyte areas and improved cardiac function compared with similarly treated wild-type mice
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• following transverse aortic constriction
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• following transverse aortic constriction
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in mice exposed to combined stresses of cold and fasting at 2 months
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• abnormal heart histology at 6 months
• decreased heart ATP content at baseline and with high workload in response to dobutamine challenge
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• frequent vacuolations
• however, cardiomyocytes exhibit normal fat accumulation and mitochondrial ultrastructure and oxidative function
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• at 6 months
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• increased left ventricular end-diastolic and end-systolic dimensions at 6, but not 3, months
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• at 6, but not 3, months
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• isolated hearts exhibit reduced systolic and diastolic function compared with control hearts
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• at 6 months
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• decreased left ventricular fractional shortening at 6 months
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• severe in cold-exposed fasted mice
• however, rewarming rescues and recovers heart rate and function
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• cold-exposed fasted mice exhibit lethargy, increased lethality, reduced respiratory exchange ratio, decreased body temperature, decreased circulating glucose and decreased heart rate and function compared with control mice
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• after 60 minutes of cold exposure and fasting
• however, glucose levels are normal prior to cold exposure
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• after 45 minutes of cold exposure and fasting
• however, body temperature prior to cold exposure is normal
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• in cold-exposed fasted mice
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• frequent vacuolations
• however, cardiomyocytes exhibit normal fat accumulation and mitochondrial ultrastructure and oxidative function
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• at 6 months
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• decreased left ventricular fractional shortening at 6 months
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• at 6 months
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice develop normally with normal life spans and cardiac structure and function and 18 week old hearts show no ventricular thinning, right ventricular dilatation or fibrosis
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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