Kdm4a^tm1Zpl
Targeted Allele Detail

Summary

• Symbol: Kdm4a^tm1Zpl
• Name: lysine (K)-specific demethylase 4A; targeted mutation 1, Zhi-Ping Liu
• MGI ID: MGI:5056131
• Synonyms: Jmjd2a^fl
• Gene: Kdm4a Location: Chr4:117994154-118037240 bp, - strand Genetic Position: Chr4, 54.31 cM
• Alliance: Kdm4a^tm1Zpl page

Kdm4a^tm1Zpl/Kdm4a^tm1Zpl Tg(Myh6-cre)1Jmk/0 mice exhibit abnormal heart phenotypes following transverse aortic constriction

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:173908
• Parent Cell Line: SM1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A loxP site was inserted upstream of exon 3. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 3. (J:173908)

Generation of the Kdm4a^tm1Zpl allele

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Kdm4a Mutation: 43 strains or lines available

References

• Original: J:173908 Zhang QJ, et al., The histone trimethyllysine demethylase JMJD2A promotes cardiac hypertrophy in response to hypertrophic stimuli in mice. J Clin Invest. 2011 Jun 1;121(6):2447-56
• All: 6 reference(s)