Rpl3l^em1Jmol
Endonuclease-mediated Allele Detail

Summary

• Symbol: Rpl3l^em1Jmol
• Name: ribosomal protein L3-like; endonuclease-mediated mutation 1, Jeffery D Molkentin
• MGI ID: MGI:7434982
• Gene: Rpl3l Location: Chr17:24946800-24955117 bp, + strand Genetic Position: Chr17, 12.52 cM, cytoband A3.3
• Alliance: Rpl3l^em1Jmol page

Mutation origin

• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology using sgRNAs 5-GTGGGCCTTCTTCTGCCGAA-3 and 5-TGGCTGAACACGCTGTGTAC-3generated a frame-shift and subsequent deletion mutation in exon 5. Western blot analysis confirmed absence of protein in heart ventricle. (J:333030)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rpl3l Mutation: 27 strains or lines available

References

• Original: J:333030 Grimes KM, et al., Rpl3l gene deletion in mice reduces heart weight over time. Front Physiol. 2023;14:1054169
• All: 1 reference(s)