Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vangl1Gt(XL802)Byg mutation
(1 available);
any
Vangl1 mutation
(85 available)
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Abnormal orientation of hair cells of the cochlea in Vangl1Gt(XL802)Byg/Vangl1Gt(XL802)Byg embryos
hearing/vestibular/ear
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• modest but significant misorientation in all hair cell layers
• however, the number and organization of hair cell rows is not different from wild-type controls
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cardiovascular system
N |
• unlike mice homozygous for Vangl2Lp alone, nor outflow tract abnormalities are detected
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nervous system
N |
• unlike mice with mutations in Vangl2, no neural tube defects are detected
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• modest but significant misorientation in all hair cell layers
• however, the number and organization of hair cell rows is not different from wild-type controls
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vangl1Gt(XL802)Byg mutation
(1 available);
any
Vangl1 mutation
(85 available)
Vangl2ska17 mutation
(0 available);
any
Vangl2 mutation
(34 available)
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normal phenotype
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• no tail, neural tube or eyelid fusion defects are detected
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reproductive system
nervous system
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• inner hair cells are misoriented compared to in wild-type mice
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• outer hair cells are misoriented compared to in wild-type mice
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limbs/digits/tail
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• compared with Vangl1Gt(XL802)Byg/Vangl1Gt(XL802)Byg Vangl2tm1.2Yy/Vangl2+
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hearing/vestibular/ear
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• inner hair cells are misoriented compared to in wild-type mice
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• outer hair cells are misoriented compared to in wild-type mice
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vangl1Gt(XL802)Byg mutation
(1 available);
any
Vangl1 mutation
(85 available)
Vangl2tm1.2Yy mutation
(0 available);
any
Vangl2 mutation
(34 available)
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embryo
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• positioning of the posterior notochord (node) cilia is randomized unlike in wild-type mice
• in the posterior notochord (node), cell density is slightly reduced and cilia localization is altered compared to in wild-type mice
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• nodal flow produces swirling vortices and time to cross the posterior notochord (node) is lengthened compared to in wild-type mice
• unilateral nodal flow in the posterior notochord (node) is compromised compared to in wild-type mice
• however, cilia in the posterior notochord beat at the same speed and direction as in wild-type mice
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• embryos fail to turn unlike wild-type mice
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• cell density and the number of posteriorly localized basal bodies in the posterior notochord (node) are decreased compared to in wild-type mice
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growth/size/body
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• embryos exhibit a reduction in length to width ratio compared with wild-type mice
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• mice exhibit left-right asymmetry defects compared with wild-type mice
• however, nodal cilia appear normal
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nervous system
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• inner hair cells are misoriented compared to in wild-type mice
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• outer hair cells are misoriented compared to in wild-type mice
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cardiovascular system
respiratory system
hearing/vestibular/ear
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• inner hair cells are misoriented compared to in wild-type mice
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• outer hair cells are misoriented compared to in wild-type mice
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cellular
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• positioning of the posterior notochord (node) cilia is randomized unlike in wild-type mice
• in the posterior notochord (node), cell density is slightly reduced and cilia localization is altered compared to in wild-type mice
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• nodal flow produces swirling vortices and time to cross the posterior notochord (node) is lengthened compared to in wild-type mice
• unilateral nodal flow in the posterior notochord (node) is compromised compared to in wild-type mice
• however, cilia in the posterior notochord beat at the same speed and direction as in wild-type mice
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vangl1Gt(XL802)Byg mutation
(1 available);
any
Vangl1 mutation
(85 available)
Vangl2tm1.2Yy mutation
(0 available);
any
Vangl2 mutation
(34 available)
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nervous system
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• outer hair cells in rows 3 and 2 are misoriented compared to in wild-type mice
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limbs/digits/tail
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• compared with Vangl2Lp/Vangl2Lp Vangl2tm1.2Yy/Vangl2+
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hearing/vestibular/ear
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• outer hair cells in rows 3 and 2 are misoriented compared to in wild-type mice
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Vangl1Gt(XL802)Byg/Vangl1+ Vangl2Lp/Vangl2+ and Vangl2Lp/Vangl2Lp embryos exhibit aberrant right subclavian artery
mortality/aging
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• fewer than expected double heterozygotes are found at weaning (20% rather than the expected 50%) given the presence of craniorachischisis late embryonic lethality is probably the cause of the distorted ratio
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nervous system
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• seen in over 60% of double heterozygotes at E13.5 - E18.5
• phenotype is as severe as in mice homozygous for Vangl2Lp alone
• no obvious neural tube defects are seen in surviving mice
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• 20% of inner hair cell bundles are misoriented
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• some bundles in all 3 layers are misoriented especially at the apical turn (over 50% of bundles in OHC1, 65% in OHC2, over 80% in OHC3)
• vertices are randomly oriented with rotation angles of 40 - 180 degrees
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cardiovascular system
N |
• unlike mice homozygous for Vangl2Lp alone, no outflow tract abnormalities are detected in double heterozygotes
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• at E14.5, the right subclavian artery is positioned dorsal to the esophagus
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hearing/vestibular/ear
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• reduced in size at E18.5 in mice displaying craniorachischisis
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• 20% of inner hair cell bundles are misoriented
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• some bundles in all 3 layers are misoriented especially at the apical turn (over 50% of bundles in OHC1, 65% in OHC2, over 80% in OHC3)
• vertices are randomly oriented with rotation angles of 40 - 180 degrees
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limbs/digits/tail
embryo
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• seen in over 60% of double heterozygotes at E13.5 - E18.5
• phenotype is as severe as in mice homozygous for Vangl2Lp alone
• no obvious neural tube defects are seen in surviving mice
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