Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dkk1tm1Sia mutation
(0 available);
any
Dkk1 mutation
(17 available)
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nervous system
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• at E7.5, anterior neuroectoderm development is abnormal
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embryo
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• at E7.5, anterior neuroectoderm development is abnormal
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dkk1tm1Sia mutation
(0 available);
any
Dkk1 mutation
(17 available)
Sfrp1tm1Aksh mutation
(0 available);
any
Sfrp1 mutation
(17 available)
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embryo
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• 50% of mice exhibit irregular somatic segmentation and indistinct intersomitic boundaries
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dkk1tm1Sia mutation
(0 available);
any
Dkk1 mutation
(17 available)
Sfrp1tm1Aksh mutation
(0 available);
any
Sfrp1 mutation
(17 available)
Sfrp2tm1Aksh mutation
(0 available);
any
Sfrp2 mutation
(26 available)
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embryo
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• intersomitic boundaries are absent in the posterior portion
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dkk1tm1Sia mutation
(0 available);
any
Dkk1 mutation
(17 available)
Sfrp1tm1Aksh mutation
(0 available);
any
Sfrp1 mutation
(17 available)
Sfrp2tm1Aksh mutation
(0 available);
any
Sfrp2 mutation
(26 available)
|
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embryo
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• pre-somitic mesoderm is reduced
• however, the notochord and tail bud mesoderm are present
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