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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dkk1tm1Sia
targeted mutation 1, Shinichi Aizawa
MGI:3777004
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Dkk1tm1Sia/Dkk1tm1Sia involves: C57BL/6 * CBA MGI:3795587
cx2
 		Dkk1tm1Sia/Dkk1tm1Sia
Sfrp1tm1Aksh/Sfrp1tm1Aksh 		involves: 129 * C57BL/6 * CBA MGI:3795550
cx3
 		Dkk1tm1Sia/Dkk1tm1Sia
Sfrp1tm1Aksh/Sfrp1tm1Aksh
Sfrp2tm1Aksh/Sfrp2+ 		involves: 129 * C57BL/6 * CBA MGI:3795551
cx4
 		Dkk1tm1Sia/Dkk1tm1Sia
Sfrp1tm1Aksh/Sfrp1tm1Aksh
Sfrp2tm1Aksh/Sfrp2tm1Aksh 		involves: 129 * C57BL/6 * CBA MGI:3795552


Genotype
MGI:3795587
hm1
Allelic
Composition		 Dkk1tm1Sia/Dkk1tm1Sia
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dkk1tm1Sia mutation (0 available); any Dkk1 mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal embryonic neuroepithelium morphology ( J:122557 )
• at E7.5, anterior neuroectoderm development is abnormal

embryo
abnormal embryonic neuroepithelium morphology ( J:122557 )
• at E7.5, anterior neuroectoderm development is abnormal




Genotype
MGI:3795550
cx2
Allelic
Composition		 Dkk1tm1Sia/Dkk1tm1Sia
Sfrp1tm1Aksh/Sfrp1tm1Aksh
Genetic
Background		 involves: 129 * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dkk1tm1Sia mutation (0 available); any Dkk1 mutation (19 available)
Sfrp1tm1Aksh mutation (1 available); any Sfrp1 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
incomplete somite formation ( J:135313 )
• 50% of mice exhibit irregular somatic segmentation and indistinct intersomitic boundaries




Genotype
MGI:3795551
cx3
Allelic
Composition		 Dkk1tm1Sia/Dkk1tm1Sia
Sfrp1tm1Aksh/Sfrp1tm1Aksh
Sfrp2tm1Aksh/Sfrp2+
Genetic
Background		 involves: 129 * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dkk1tm1Sia mutation (0 available); any Dkk1 mutation (19 available)
Sfrp1tm1Aksh mutation (1 available); any Sfrp1 mutation (17 available)
Sfrp2tm1Aksh mutation (1 available); any Sfrp2 mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
incomplete somite formation ( J:135313 )
• intersomitic boundaries are absent in the posterior portion




Genotype
MGI:3795552
cx4
Allelic
Composition		 Dkk1tm1Sia/Dkk1tm1Sia
Sfrp1tm1Aksh/Sfrp1tm1Aksh
Sfrp2tm1Aksh/Sfrp2tm1Aksh
Genetic
Background		 involves: 129 * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dkk1tm1Sia mutation (0 available); any Dkk1 mutation (19 available)
Sfrp1tm1Aksh mutation (1 available); any Sfrp1 mutation (17 available)
Sfrp2tm1Aksh mutation (1 available); any Sfrp2 mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
abnormal presomitic mesoderm morphology ( J:135313 )
• pre-somitic mesoderm is reduced
• however, the notochord and tail bud mesoderm are present




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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory