Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(DTA)Riet mutation
(0 available);
any
Gt(ROSA)26Sor mutation
(942 available)
Tg(Gnrh1-cre)1Dlc mutation
(1 available)
Tg(Pomc-EGFP)1Low mutation
(1 available)
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reproductive system
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• less pronounced than in Nhlh2tm2Thbr/Nhlh2tm2Thbr Tg(CMV-cre)1Cgn mice
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• less pronounced than in Nhlh2tm2Thbr/Nhlh2tm2Thbr Tg(CMV-cre)1Cgn mice
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nervous system
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• severe reduction in Pomc+ neurons
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adipose tissue
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• increased visceral fat mass
• however, subcutaneous adipose weight is normal
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endocrine/exocrine glands
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• less pronounced than in Nhlh2tm2Thbr/Nhlh2tm2Thbr Tg(CMV-cre)1Cgn mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nhlh2tm1Thbr mutation
(0 available);
any
Nhlh2 mutation
(13 available)
Tg(Pomc-EGFP)1Low mutation
(1 available)
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nervous system
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• Pomc+ neurons at 15 to 21 weeks in the medial preoptic area and posterior hypothalamus
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• Pomc+ neurons in female mice at 3 and 6 weeks in the medial preoptic area, posterior hypothalamus and arcuate nuclei of the hypothalamus with ectopic neurons in the medial mammillary nucleus
• however, the numbers decline after 9 weeks with the onset of puberty
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• ectopic Pomc+ neurons in female mice at 3 and 6 weeks in the medial mammillary nucleus
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nhlh2tm2Thbr mutation
(0 available);
any
Nhlh2 mutation
(13 available)
Tg(Gnrh1-cre)1Dlc mutation
(1 available)
Tg(Pomc-EGFP)1Low mutation
(1 available)
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reproductive system
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N |
• mice exhibit normal uteri and testis weights
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nervous system
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• severe reduction in Pomc+ neurons in the medial preoptic area and posterior hypothalamus in male and female mice
• reduced Gnhr+ neurons in male and female mice
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adipose tissue
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• increased visceral fat mass weight in male and female mice but not as much as in Nhlh2tm2Thbr/Nhlh2tm2Thbr Tg(CMV-cre)1Cgn mice
• however, subcutaneous adipose weight is normal
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homeostasis/metabolism
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nhlh2tm2Thbr mutation
(0 available);
any
Nhlh2 mutation
(13 available)
Tg(Pomc1-cre)16Lowl mutation
(1 available)
Tg(Pomc-EGFP)1Low mutation
(1 available)
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reproductive system
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N |
• mice exhibit normal uteri weight and fertility
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nervous system
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N |
• mice exhibit normal numbers of Gnrh+ neurons
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growth/size/body
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N |
• mice exhibit normal weight
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adipose tissue
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N |
• mice exhibit normal visceral and subcutaneous fat depots
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agrptm2(HBEGF)Rpa mutation
(1 available);
any
Agrp mutation
(18 available)
Tg(Pomc-EGFP)1Low mutation
(1 available)
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growth/size/body
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• adult mice treated with diptheria toxin (DT) to specifically ablate NPY-expressing cells exhibit 20% of their body weight unlike similarly treated wild-type mice
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nervous system
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• mice treated with diptheria toxin (DT) to specifically ablate NPY-expressing cells exhibit miniature inhibitory postsynaptic currents that are 6-fold lower than in wild-type mice and lower than in fasted wild-type mice
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Analysis Tools