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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hfetm1Wsr
targeted mutation 1, Wolfgang Stremmel
MGI:3775647
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Hfetm1Wsr/Hfetm1Wsr
Lyz2tm1(cre)Ifo/? 		involves: 129P2/OlaHsd * C57BL/6 MGI:3775663
cn2
 		Hfetm1Wsr/Hfetm1Wsr
Tg(Alb1-cre)7Gsc/? 		involves: 129P2/OlaHsd * C57BL/6 * FVB/N MGI:3775662
cn3
 		Hfetm1Wsr/Hfetm1Wsr
Tg(Vil1-cre)997Gum/? 		involves: 129P2/OlaHsd * C57BL/6 * SJL MGI:3821583


Genotype
MGI:3775663
cn1
Allelic
Composition		 Hfetm1Wsr/Hfetm1Wsr
Lyz2tm1(cre)Ifo/?
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hfetm1Wsr mutation (0 available); any Hfe mutation (34 available)
Lyz2tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
homeostasis/metabolism phenotype ( J:132134 )
N
• iron homeostasis is normal in these mice




Genotype
MGI:3775662
cn2
Allelic
Composition		 Hfetm1Wsr/Hfetm1Wsr
Tg(Alb1-cre)7Gsc/?
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hfetm1Wsr mutation (0 available); any Hfe mutation (34 available)
Tg(Alb1-cre)7Gsc mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased spleen iron level ( J:132134 )
• non-heme splenic iron levels are significantly reduced compared to littermate controls
increased circulating iron level ( J:132134 )
• plasma iron levels are significantly elevated compared to age and sex matched controls
• transferrin saturation is significantly elevated and the unsaturated iron binding capacity is significantly reduced
increased liver iron level ( J:132134 )
• iron accumulates in the parenchymal cells of the liver
• iron levels are 3- to 6- fold higher than littermate controls
hemochromatosis ( J:132134 )
• symptoms in mice are consistent with hemocromatosis

hematopoietic system
decreased spleen iron level ( J:132134 )
• non-heme splenic iron levels are significantly reduced compared to littermate controls

immune system
decreased spleen iron level ( J:132134 )
• non-heme splenic iron levels are significantly reduced compared to littermate controls

liver/biliary system
increased liver iron level ( J:132134 )
• iron accumulates in the parenchymal cells of the liver
• iron levels are 3- to 6- fold higher than littermate controls




Genotype
MGI:3821583
cn3
Allelic
Composition		 Hfetm1Wsr/Hfetm1Wsr
Tg(Vil1-cre)997Gum/?
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hfetm1Wsr mutation (0 available); any Hfe mutation (34 available)
Tg(Vil1-cre)997Gum mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:141745 )
• mice are viable, fertile and have no detectable defects in iron homeostasis

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
NOT hemochromatosis type 1 DOID:0111029 OMIM:235200
 J:141745




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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory