All Phenotypes Prkar2b<tm2Gsm> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Prkar2b^tm2Gsm
targeted mutation 2, G Stanley McKnight
MGI:3773428

Summary

12 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Prkar2b^tm2Gsm/Prkar2b^tm2Gsm	involves: C57BL/6	MGI:3773450
ht2	Prkar2b^tm2Gsm/Prkar2b⁺	involves: C57BL/6	MGI:3773451
cn3	Prkar2b^tm3Gsm/Prkar2b^tm2Gsm Slc32a1^tm2(cre)Lowl/Slc32a1⁺	involves: 129S6/SvEvTac * C57BL/6	MGI:5515339
cn4	Prkar2b^tm3Gsm/Prkar2b^tm2Gsm Tg(Fabp4-cre)1Rev/0	involves: C57BL/6	MGI:5515332
cn5	Prkar2b^tm3Gsm/Prkar2b^tm2Gsm Tg(Ppp1r1b-cre)1Meeh/0	involves: C57BL/6	MGI:5515335
cn6	Prkar2b^tm3Gsm/Prkar2b^tm2Gsm Drd1^tm1(cre)Rpa/Drd1⁺	involves: C57BL/6	MGI:5515336
cn7	Prkar2b^tm3Gsm/Prkar2b^tm2Gsm Tg(Syn1-cre)671Jxm/0	involves: C57BL/6 * CBA	MGI:5515333
cn8	Prkar2b^tm3Gsm/Prkar2b^tm2Gsm Tg(Ins2-cre)25Mgn/0	involves: C57BL/6 * DBA	MGI:5515338
cn9	Prkar2b^tm3Gsm/Prkar2b^tm2Gsm Tg(Drd2-cre)ER44Gsat/0	involves: C57BL/6 * FVB/N	MGI:5515337
cn10	Prkar2b^tm3Gsm/Prkar2b^tm2Gsm Tg(Nes-cre)1Kln/0	involves: C57BL/6 * SJL	MGI:5515334
cx11	A^y/A Prkar2b^tm2Gsm/Prkar2b^tm2Gsm	involves: C57BL/6	MGI:3773448
cx12	A^y/A Prkar2b^tm2Gsm/Prkar2b⁺	involves: C57BL/6	MGI:3773449

Allelic Composition	Prkar2b^tm2Gsm/Prkar2b^tm2Gsm
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkar2b^tm2Gsm mutation (1 available); any Prkar2b mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

adipose tissue

decreased percent body fat/body weight ( J:131039 )

• female percentage body fat is reduced by about a third

behavior/neurological

increased locomotor activity ( J:131039 )

• locomotor activity is 1.5 to 2-fold that of wild-type controls

Allelic Composition	Prkar2b^tm2Gsm/Prkar2b⁺
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkar2b^tm2Gsm mutation (1 available); any Prkar2b mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

adipose tissue

decreased percent body fat/body weight ( J:131039 )

• percentage body fat in females is reduced by about 25%

• percentage body fat in males is reduced by about 14%

behavior/neurological

polyphagia ( J:131039 )

• mice are slightly hyperphagic

homeostasis/metabolism

decreased circulating leptin level ( J:131039 )

• leptin level are reduced by about 60%

Allelic Composition	Prkar2b^tm3Gsm/Prkar2b^tm2Gsm Slc32a1^tm2(cre)Lowl/Slc32a1⁺
Genetic Background	involves: 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkar2b^tm2Gsm mutation (1 available); any Prkar2b mutation (27 available)
Prkar2b^tm3Gsm mutation (0 available); any Prkar2b mutation (27 available)
Slc32a1^tm2(cre)Lowl mutation (2 available); any Slc32a1 mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:196157 )

N	• hyperactivity phenotype is reversed

growth/size/body

growth/size/body region phenotype ( J:196157 )

N	• lean body mass is similar to controls

adipose tissue

adipose tissue phenotype ( J:196157 )

N	• fat pad weights are similar to controls

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:196157 )

N	• serum leptin levels similar to controls

Allelic Composition	Prkar2b^tm3Gsm/Prkar2b^tm2Gsm Tg(Fabp4-cre)1Rev/0
Genetic Background	involves: C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

increased locomotor activity ( J:196157 )

• hyper-locomotor activity is retained

adipose tissue

decreased total body fat amount ( J:196157 )

decreased gonadal fat pad weight ( J:196157 )

• reproductive fat pads weigh significantly less in both males and females

growth/size/body

decreased body weight ( J:196157 )

homeostasis/metabolism

decreased circulating leptin level ( J:196157 )

• low serum leptin levels

Allelic Composition	Prkar2b^tm3Gsm/Prkar2b^tm2Gsm Tg(Ppp1r1b-cre)1Meeh/0
Genetic Background	involves: C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:196157 )

N	• locomotor behavior comparable to controls

growth/size/body

decreased lean body mass ( J:196157 )

• lean body weight remains low

homeostasis/metabolism

decreased circulating leptin level ( J:196157 )

• serum leptin levels remain low

Allelic Composition	Prkar2b^tm3Gsm/Prkar2b^tm2Gsm Drd1^tm1(cre)Rpa/Drd1⁺
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Drd1^tm1(cre)Rpa mutation (0 available); any Drd1 mutation (68 available)
Prkar2b^tm2Gsm mutation (1 available); any Prkar2b mutation (27 available)
Prkar2b^tm3Gsm mutation (0 available); any Prkar2b mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

hyperactivity ( J:196157 )

• remain hyperactive

growth/size/body

growth/size/body region phenotype ( J:196157 )

N	• body weight similar to controls

adipose tissue

adipose tissue phenotype ( J:196157 )

N	• adiposity similar to controls

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:196157 )

N	• serum leptin levels similar to controls

Allelic Composition	Prkar2b^tm3Gsm/Prkar2b^tm2Gsm Tg(Syn1-cre)671Jxm/0
Genetic Background	involves: C57BL/6 * CBA

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:196157 )

N	• locomotor behavior restored to normal

growth/size/body

growth/size/body region phenotype ( J:196157 )

N	• body weight restored to normal

adipose tissue

adipose tissue phenotype ( J:196157 )

N	• major fat pads are comparable to controls

Allelic Composition	Prkar2b^tm3Gsm/Prkar2b^tm2Gsm Tg(Ins2-cre)25Mgn/0
Genetic Background	involves: C57BL/6 * DBA

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:196157 )

N	• hyperactivity phenotype is reduced

growth/size/body

growth/size/body region phenotype ( J:196157 )

N	• body weight similar to controls • lean body mass is similar to controls

adipose tissue

adipose tissue phenotype ( J:196157 )

N	• adiposity similar to controls

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:196157 )

N	• serum leptin levels similar to controls

Allelic Composition	Prkar2b^tm3Gsm/Prkar2b^tm2Gsm Tg(Drd2-cre)ER44Gsat/0
Genetic Background	involves: C57BL/6 * FVB/N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:196157 )

N	• hyperactivity phenotype is lost

adipose tissue

decreased total body fat amount ( J:196157 )

• low adiposity

growth/size/body

decreased body weight ( J:196157 )

• low body weight

• lean body

homeostasis/metabolism

decreased circulating leptin level ( J:196157 )

• low serum leptin levels

Allelic Composition	Prkar2b^tm3Gsm/Prkar2b^tm2Gsm Tg(Nes-cre)1Kln/0
Genetic Background	involves: C57BL/6 * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:196157 )

N	• locomotor behavior restored to normal

growth/size/body

growth/size/body region phenotype ( J:196157 )

N	• body weight restored to normal

adipose tissue

adipose tissue phenotype ( J:196157 )

N	• major fat pads are comparable to controls

Allelic Composition	A^y/A Prkar2b^tm2Gsm/Prkar2b^tm2Gsm
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (19 available); any a mutation (463 available)
A^y mutation (12 available); any a mutation (463 available)
Prkar2b^tm2Gsm mutation (1 available); any Prkar2b mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

adipose tissue

increased brown adipose tissue amount ( J:131039 )

• female mice have a 2-fold gain in mg of BAT compared to littermate controls

increased gonadal fat pad weight ( J:131039 )

• female mice have almost a 2-fold increase in fat pad weight compared to wild-type controls

increased inguinal fat pad weight ( J:131039 )

• female mice have about a 2-fold increase in fat pad weight compared to wild-type controls

increased retroperitoneal fat pad weight ( J:131039 )

• female mice have about a 2-fold increase in fat pad weight compared to wild-type controls

increased percent body fat/body weight ( J:131039 )

• female and male mice have a 1.6-fold gain in percentage of body fat compared to littermate controls

behavior/neurological

behavior/neurological phenotype ( J:131039 )

N	• food consumption and circulating levels of leptin are close to wild-type levels, which is significantly less compared to mice with only the A^y mutant allele

increased locomotor activity ( J:131039 )

• locomotor activity is about 1.5-fold higher compared to wild-type control mice

growth/size/body

growth/size/body region phenotype ( J:131039 )

• mean body weight and length of 20-23 week old mice is similar to wild-type littermate controls and is less than is observed in mice with only the A^y mutant allele

• weight and percentage of body fat in female mice is higher than in wild-type mice but is significantly lower than is observed in mice with only the A^y mutant allele

increased susceptibility to weight gain ( J:131039 )

• male but not female mice gain weight at a greater rate than littermate controls starting at six weeks of age

• rate of weight gain in male mice is significantly less than in A^y heterozygotes

pigmentation

yellow coat color ( J:131039 )

• mice have a yellow coat color

integument

yellow coat color ( J:131039 )

• mice have a yellow coat color

Allelic Composition	A^y/A Prkar2b^tm2Gsm/Prkar2b⁺
Genetic Background	involves: C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

adipose tissue

increased percent body fat/body weight ( J:131039 )

• mice have increased percentage of body fat but is 10% less than what is observed in A^y heterozygotes

behavior/neurological

polyphagia ( J:131039 )

• mice have a higher food consumption but is about 10% less than the amount A^y heterozygotes consume

growth/size/body

increased susceptibility to weight gain ( J:131039 )

• mice have increased rate of weight growth compared to wild-type mice but significantly less than in A^y heterozygotes

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