Analysis Tools|
Allele Symbol Allele Name Allele ID |
Scd1tm2Ntam targeted mutation 2, James M Ntambi MGI:3773308 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• decreased hair shaft
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• loss of matrix progenitors
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• loss of dermal papilla cells
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• resistant to high carbohydrate and high-sucrose very low-fat, but not high fat, diet-induced obesity
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• reduced by 51% in mice on a high-sucrose very low-fat diet compared to diet matched controls
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• on a high carbohydrate diet weights of the gonadal, retroperitioneal, and inguinal fat pads are reduced by about 49% - 59% compared to controls lacking the cre transgene
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• reduced weight on a high carbohydrate diet compared to diet matched controls
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• reduced weight on a high carbohydrate diet compared to diet matched controls
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• reduced weight on a high carbohydrate diet compared to diet matched controls
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| N |
• unlike global null mice, no difference is seen in plasma glucose and insulin levels, glucose clearance or insulin sensitivity between liver knockout mice and controls on a high carbohydrate diet
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• resistant to high carbohydrate and high-sucrose very low-fat, but not high fat, diet-induced obesity
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• reduced in mice on a high-sucrose very low-fat diet compared to diet matched controls
• but not in mice on high carbohydrate, high fat, or chow diet
• supplementing the high-sucrose very low-fat diet with oleate prevents the decrease in plasma glucose levels
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• impaired production of glucose from pyruvate in mice fed a high-sucrose very low-fat diet
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• reduced glycogen levels in the liver in mice on a high-sucrose very low-fat diet compared to diet matched controls
• supplementing the diet with oleate prevents the decrease in hepatic glycogen levels
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• 85% decrease in hepatic lipogenesis in mice on a high carbohydrate diet
• however, cholesterol synthesis is unaffected
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• develops in mice on a high-sucrose very low-fat diet, probably due to increases in HDL and LDL cholesterol
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• in mice on a high carbohydrate diet compared to diet-matched controls
• however, levels are similar to controls in mice on a chow or high fat diet
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• significant reduction in mice on a high carbohydrate or a high-sucrose very low-fat diet compared to diet-matched controls
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• on a high carbohydrate or diet high-sucrose very low-fat diet, liver triglyceride levels are reduced by 69% or 49%, respectively, compared to controls
• fasted mice refed a fat free high carbohydrate diet have lower liver levels of SCD1 products including palmitoleate and oleate
• supplementing the diet with triolein reduces the decrease in liver triglyceride levels
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• reduced glycogen levels in the liver in mice on a high-sucrose very low-fat diet compared to diet matched controls
• supplementing the diet with oleate prevents the decrease in hepatic glycogen levels
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• on a high carbohydrate or diet high-sucrose very low-fat diet, liver triglyceride levels are reduced by 69% or 49%, respectively, compared to controls
• fasted mice refed a fat free high carbohydrate diet have lower liver levels of SCD1 products including palmitoleate and oleate
• supplementing the diet with triolein reduces the decrease in liver triglyceride levels
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• resistant to high carbohydrate and high-sucrose very low-fat, but not high fat, diet-induced fatty liver development
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• block in carbohydrate-induce hepatic lipogenesis
• a high-sucrose very low-fat diet fails to increase the rate of triglyceride secretion, unlike in controls
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| N |
• unlike global null mice, no difference in food intake is seen in mice on a chow diet
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 09/30/2025 MGI 6.24 |
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