Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrig1tm1.1(cre/ERT2)Rjc mutation
(1 available);
any
Lrig1 mutation
(49 available)
Scd1tm2Ntam mutation
(0 available);
any
Scd1 mutation
(24 available)
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integument
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• loss of matrix progenitors
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• loss of dermal papilla cells
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scd1tm2Ntam mutation
(0 available);
any
Scd1 mutation
(24 available)
Speer6-ps1Tg(Alb-cre)21Mgn mutation
(6 available);
any
Speer6-ps1 mutation
(4 available)
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growth/size/body
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• resistant to high carbohydrate and high-sucrose very low-fat, but not high fat, diet-induced obesity
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adipose tissue
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• reduced by 51% in mice on a high-sucrose very low-fat diet compared to diet matched controls
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• on a high carbohydrate diet weights of the gonadal, retroperitioneal, and inguinal fat pads are reduced by about 49% - 59% compared to controls lacking the cre transgene
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• reduced weight on a high carbohydrate diet compared to diet matched controls
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• reduced weight on a high carbohydrate diet compared to diet matched controls
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• reduced weight on a high carbohydrate diet compared to diet matched controls
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homeostasis/metabolism
liver/biliary system
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• reduced glycogen levels in the liver in mice on a high-sucrose very low-fat diet compared to diet matched controls
• supplementing the diet with oleate prevents the decrease in hepatic glycogen levels
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• on a high carbohydrate or diet high-sucrose very low-fat diet, liver triglyceride levels are reduced by 69% or 49%, respectively, compared to controls
• fasted mice refed a fat free high carbohydrate diet have lower liver levels of SCD1 products including palmitoleate and oleate
• supplementing the diet with triolein reduces the decrease in liver triglyceride levels
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• resistant to high carbohydrate and high-sucrose very low-fat, but not high fat, diet-induced fatty liver development
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• block in carbohydrate-induce hepatic lipogenesis
• a high-sucrose very low-fat diet fails to increase the rate of triglyceride secretion, unlike in controls
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behavior/neurological
N |
• unlike global null mice, no difference in food intake is seen in mice on a chow diet
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