Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sulf2Gt(OST311938)Lex mutation
(1 available);
any
Sulf2 mutation
(176 available)
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growth/size/body
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• at 16 to 18 months of age, female mice weigh 38% less (24.6+/-1.6 g compared to 39.6+/-3.7 g for wild-type mice)
• at 14 to 15 weeks of age male mice exhibit a 20% reduction in body weight (23.3+/-0.8 g compared to 29.3+/-0.6 g for wild-type mice)
• all organs except the kidney exhibit proportional decrease in weight
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renal/urinary system
Sulf1Gt(OST352220)Lex/Sulf1Gt(OST352220)Lex Sulf2Gt(OST311938)Lex/Sulf2Gt(OST311938)Lex embryos display several development defects
mortality/aging
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• long term survival is 18%
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• some mice that survive weaning die within 10 days of weaning
• long term survival is 18%
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• fewer than expected mice survive postnatal day 1 to 2 and die with empty stomachs
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• few mice that survive past the first week of life survive to weaning
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growth/size/body
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• mice weigh 19% less than wild-type mice
• at week 14 to 15, male mice weigh 26% less than wild-type mice and female mice weigh 29% less than wild-type mice
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• mice measure 12% less in length than wild-type mice
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skeleton
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• the posterior basisphenoid bone fails to fuse and is aberrantly fused to the basioccipital bone
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• at E18.5, 12 of 14 mice exhibit asymmetric and/or fused sternebrae compared to only 1 of 19 wild-type mice
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• at E18.5, 12 of 14 mice exhibit asymmetric and/or fused sternebrae compared to only 1 of 19 wild-type mice
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• bone volume is decreased in the humerus (by 21.4%), femur (by 15.7%), frontal (by 6.8%), interparietal (by 15.3%, supraoccipital (by 22.6%), basioccipital (by 15.5%, and basiphenoid (by 13.6%)
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• the distal chondrocyte population is smaller than in wild-type mice
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renal/urinary system
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• kidney volume is reduced 45% compared to in heterogygous mice
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craniofacial
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• the posterior basisphenoid bone fails to fuse and is aberrantly fused to the basioccipital bone
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