Phenotypes associated with this allele
Allelic
Composition |
Osr2tm2(cre)Jian/Osr2+
|
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Genetic
Background |
involves: 129S1/Sv * C57BL/6 |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Osr2tm2(cre)Jian mutation
(1 available);
any
Osr2 mutation
(17 available)
|
|
|
normal phenotype
|
|
• mice do not display any obvious defects
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gsk3btm1.1Ypc mutation
(0 available);
any
Gsk3b mutation
(111 available)
Osr2tm2(cre)Jian mutation
(1 available);
any
Osr2 mutation
(17 available)
|
|
|
mortality/aging
|
N |
• unlike germline null mice, mice survive postnatally
|
craniofacial
|
N |
• unlike in germline null mice, palate formation is normal
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hand2tm1Cse mutation
(0 available);
any
Hand2 mutation
(12 available)
Osr2tm2(cre)Jian mutation
(1 available);
any
Osr2 mutation
(17 available)
|
|
|
craniofacial
|
|
• mandible is hypoplastic
• cleft palate is not observed
|
skeleton
|
|
• mandible is hypoplastic
• cleft palate is not observed
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Osr2tm2(cre)Jian mutation
(1 available);
any
Osr2 mutation
(17 available)
Tg(CAG-Nog)1Ych mutation
(0 available)
|
|
|
craniofacial
skeleton
digestive/alimentary system
growth/size/body
skeleton
|
|
• unlike in wild-type mice, strong Caspase3 activity is detected in the enamel knot cells of the maxillary and mandibular first molar tooth germs at E14.5
• however, no increase in cell death in tooth epithelium and mesenchyme is detected
|
|
|
• incisor development arrests at bud stage
|
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• molar development arrests at bud stage
|
mortality/aging
craniofacial
|
|
• unlike in wild-type mice, strong Caspase3 activity is detected in the enamel knot cells of the maxillary and mandibular first molar tooth germs at E14.5
• however, no increase in cell death in tooth epithelium and mesenchyme is detected
|
|
|
• incisor development arrests at bud stage
|
|
|
• molar development arrests at bud stage
|
digestive/alimentary system
growth/size/body
|
|
• unlike in wild-type mice, strong Caspase3 activity is detected in the enamel knot cells of the maxillary and mandibular first molar tooth germs at E14.5
• however, no increase in cell death in tooth epithelium and mesenchyme is detected
|
|
|
• incisor development arrests at bud stage
|
|
|
• molar development arrests at bud stage
|
skeleton
|
|
• at E13.5, joints are not as clearly organized as in wild-type mice
|
craniofacial
|
N |
• newborns do not exhibit cleft palate and tongues and mandibles are unaffected
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Osr2tm2(cre)Jian mutation
(1 available);
any
Osr2 mutation
(17 available)
Tg(CAG-Bmp4,-EGFP)1Ypc mutation
(0 available)
|
|
|
craniofacial
|
|
• at the anterior level, the palatal shelves elevate but fail to contact
• however, origin of palatal shelves form the maxillary processes remains unaltered
|
|
|
• at the posterior level, the palatal shelves remain at the vertical orientation, showing abnormal fusion with the mandible
|
digestive/alimentary system
|
|
• at the anterior level, the palatal shelves elevate but fail to contact
• however, origin of palatal shelves form the maxillary processes remains unaltered
|
|
|
• at the posterior level, the palatal shelves remain at the vertical orientation, showing abnormal fusion with the mandible
|
growth/size/body
|
|
• at the anterior level, the palatal shelves elevate but fail to contact
• however, origin of palatal shelves form the maxillary processes remains unaltered
|
|
|
• at the posterior level, the palatal shelves remain at the vertical orientation, showing abnormal fusion with the mandible
|
Analysis Tools
