Phenotypes associated with this allele
Allelic
Composition |
Stat3tm1Xyfu/Stat3+
|
|
Genetic
Background |
involves: 129S1/Sv * C57BL/6 |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat3tm1Xyfu mutation
(1 available);
any
Stat3 mutation
(70 available)
|
|
|
mortality/aging
|
|
• mortality during the first 12 hours following 70% hepatectomy is 5.5%
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptpn11tm1Gsf mutation
(0 available);
any
Ptpn11 mutation
(43 available)
Stat3tm1Xyfu mutation
(1 available);
any
Stat3 mutation
(70 available)
Tg(Six3-cre)69Frty mutation
(2 available)
|
|
|
vision/eye
|
|
• much thinner at age P21, more severe than in mice with wildtype Stat3 allele
|
|
|
• severe reduction at age P21, more severe than in mice with wildtype Stat3 allele
|
|
|
• severe reduction at age P21, more severe than in mice with wildtype Stat3 allele
|
|
|
• severe reduction at age P21, more severe than in mice with wildtype Stat3 allele
|
|
|
• much thinner at age P21, more severe than in mice with wildtype Stat3 allele
|
|
|
• largely disappeared at age P21, more severe than in mice with wildtype Stat3 allele
|
|
|
• much thinner at age P21, more severe than in mice with wildtype Stat3 allele
|
nervous system
|
|
• much thinner at age P21, more severe than in mice with wildtype Stat3 allele
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat3tm1.1Xyfu mutation
(0 available);
any
Stat3 mutation
(70 available)
Stat3tm1Xyfu mutation
(1 available);
any
Stat3 mutation
(70 available)
Tg(Ttr-cre)10-3Xyfu mutation
(0 available)
|
|
|
mortality/aging
|
|
• mortality during the first 12 hours following a 70% hepatectomy is 35.3% compared to 5.5% in Stat3tm1Xyfu homozygotes
• however, mortality rates after 72 hours are similar
|
liver/biliary system
|
|
• following a 70% hepatectomy or carbon tetrachloride injection, hepatocyte proliferation is less than in Stat3tm1Xyfu homozygotes
• however, liver regeneration following hepatectomy is completed
|
immune system
|
|
• following carbon tetrachloride injection
|
|
|
• following carbon tetrachloride injection
|
hematopoietic system
|
|
• following carbon tetrachloride injection
|
|
|
• following carbon tetrachloride injection
|
cellular
|
|
• following a 70% hepatectomy or carbon tetrachloride injection, hepatocyte proliferation is less than in Stat3tm1Xyfu homozygotes
• however, liver regeneration following hepatectomy is completed
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat3tm1.1Xyfu mutation
(0 available);
any
Stat3 mutation
(70 available)
Stat3tm1Xyfu mutation
(1 available);
any
Stat3 mutation
(70 available)
Tg(Myh6-cre)2182Mds mutation
(3 available)
|
|
|
cardiovascular system
|
|
• at 200 days, mice exhibit increased left ventricular chamber size compared with wild-type mice
|
|
|
• mild at 6 months
• severe at 9 months
|
|
|
• doxorubicin-treated mice exhibit a greater decrease in cardiac systolic function compared with similarly treated wild-type mice
|
|
|
• LPS-treated mice exhibit increased myocyte apoptosis compared with similarly treated wild-type mice
|
immune system
|
|
• in the cardiac myocytes of LPS-treated mice
|
|
|
• LPS-treated mice exhibit increased myocyte apoptosis and TNF-alpha levels in cardiac myocytes compared with similarly treated wild-type mice
|
homeostasis/metabolism
respiratory system
growth/size/body
muscle
|
|
• LPS-treated mice exhibit increased myocyte apoptosis compared with similarly treated wild-type mice
|
cellular
|
|
• LPS-treated mice exhibit increased myocyte apoptosis compared with similarly treated wild-type mice
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat3tm1Xyfu mutation
(1 available);
any
Stat3 mutation
(70 available)
Tg(Myh6-cre)2182Mds mutation
(3 available)
|
|
|
immune system
|
|
• in the cardiac myocytes of LPS-treated mice
|
|
|
• LPS-treated mice exhibit increased TNF-alpha levels in cardiac myocytes compared with similarly treated wild-type mice although not as severely as in homozygous mice
|
cardiovascular system
Analysis Tools
