About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		EpoTg(TAg/Epo)134.3LCPjr
transgene insertion 134.3 LC, Peter J Ratcliffe
MGI:3767166
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		EpoTg(TAg/Epo)134.3LCPjr/EpoTg(TAg/Epo)134.3LCPjr (C57BL/10 x CBA)F1 X CFLP MGI:3767175
hm2
 		EpoTg(TAg/Epo)134.3LCPjr/EpoTg(TAg/Epo)134.3LCPjr involves: C57BL/6 * CBA MGI:3767176
ht3
 		EpoTg(TAg/Epo)134.3LCPjr/Epo+ (C57BL/10 x CBA)F1 X CFLP MGI:3767174
ht4
 		EpoTg(TAg/Epo)134.3LCPjr/Epo+ involves: C57BL/6 * CBA MGI:3767178


Genotype
MGI:3767175
hm1
Allelic
Composition		 EpoTg(TAg/Epo)134.3LCPjr/EpoTg(TAg/Epo)134.3LCPjr
Genetic
Background		 (C57BL/10 x CBA)F1 X CFLP
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
EpoTg(TAg/Epo)134.3LCPjr mutation (3 available); any Epo mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
anemia ( J:128415 )
• mice have a 70% reduction in hemocrit values




Genotype
MGI:3767176
hm2
Allelic
Composition		 EpoTg(TAg/Epo)134.3LCPjr/EpoTg(TAg/Epo)134.3LCPjr
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
EpoTg(TAg/Epo)134.3LCPjr mutation (3 available); any Epo mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased spleen weight ( J:79374 )
• six fold increase in spleen weight
anemia ( J:79374 , J:128248 )
• mice have a 66% reduction in hemocrit values (J:79374)
• mice have a 60% reduction in hemocrit values (J:128248)

homeostasis/metabolism
decreased oxygen consumption ( J:128248 )
• maximum oxygen consumption is reduced by 30%
hyperoxia ( J:128248 )
• 11% increase in arterial partial O2 levels compared to wild-type mice
hypoxia ( J:79374 )
• hypoxia occurs in hindlimb skeletal muscle as determined by increased CD31 and VEGF expression
hemosiderosis ( J:79374 )
• livers show an increase in the amount of nonheme iron in the cytoplasm of the Kupffer and parenchymal cells

cardiovascular system
increased myocardial fiber size ( J:79374 )
• 20% increase in the length of the sarcomeres
increased heart weight ( J:79374 )
• two fold increase in heart weight that is consistent with anemia-associated hypertrophy
increased heart left ventricle weight ( J:128248 )
• 27% increase in weight
increased heart right ventricle weight ( J:128242 , J:128248 )
• no further increases in weight occur when mice are hypoxic for 2 weeks (J:128242)
• 44% average increase in weight (J:128248)

muscle
increased myocardial fiber size ( J:79374 )
• 20% increase in the length of the sarcomeres

immune system
increased spleen weight ( J:79374 )
• six fold increase in spleen weight

respiratory system
increased pulmonary ventilation ( J:128242 , J:128248 )
• mice increase their ventilation with acclimatization to hypoxia (J:128242)
• ventilation under normoxia conditions is increased almost 1.7 fold due to larger tidal volumes of each respiration (J:128248)
hyperventilation ( J:128248 )
• mice have an increased respiratory rate when subjected to hypoxic conditions

growth/size/body
increased heart weight ( J:79374 )
• two fold increase in heart weight that is consistent with anemia-associated hypertrophy
increased spleen weight ( J:79374 )
• six fold increase in spleen weight




Genotype
MGI:3767174
ht3
Allelic
Composition		 EpoTg(TAg/Epo)134.3LCPjr/Epo+
Genetic
Background		 (C57BL/10 x CBA)F1 X CFLP
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
EpoTg(TAg/Epo)134.3LCPjr mutation (3 available); any Epo mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
anemia ( J:128415 )
• mice have a 25% reduction in hemocrit values




Genotype
MGI:3767178
ht4
Allelic
Composition		 EpoTg(TAg/Epo)134.3LCPjr/Epo+
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
EpoTg(TAg/Epo)134.3LCPjr mutation (3 available); any Epo mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
anemia ( J:79374 )
• mice have a 32% reduction in hemocrit values




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory