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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ptger3tm1Csml
targeted mutation 1, Clifford B Saper
MGI:3764893
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ptger3tm1Csml/Ptger3tm1Csml involves: 129S4/SvJae * C57BL/6 MGI:3764894
cn2
 		Ptger3tm1Csml/Ptger3tm1Csml involves: 129S4/SvJae * C57BL/6 MGI:3764895
cn3
 		Ptger3tm1Csml/Ptger3tm1Csml
Tg(Nes-cre)1Kln/? 		involves: 129S4/SvJae * C57BL/6 * SJL MGI:3764896


Genotype
MGI:3764894
hm1
Allelic
Composition		 Ptger3tm1Csml/Ptger3tm1Csml
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptger3tm1Csml mutation (1 available); any Ptger3 mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
homeostasis/metabolism phenotype ( J:127396 )
N
• mice exhibit a normal fever response to injection of PGE3 or LPS




Genotype
MGI:3764895
cn2
Allelic
Composition		 Ptger3tm1Csml/Ptger3tm1Csml
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptger3tm1Csml mutation (1 available); any Ptger3 mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
impaired febrile response ( J:127396 )
• following treatment with an adenoviral-cre vector, fever response induced by PGE3 or LPS is attenuated




Genotype
MGI:3764896
cn3
Allelic
Composition		 Ptger3tm1Csml/Ptger3tm1Csml
Tg(Nes-cre)1Kln/?
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptger3tm1Csml mutation (1 available); any Ptger3 mutation (22 available)
Tg(Nes-cre)1Kln mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
impaired adaptive thermogenesis ( J:127396 )
• unlike wild-type mice, mice exhibit mild hypothermia when injected with PGE3 or LPS
impaired febrile response ( J:127396 )
• fever response induced by LPS and PGE3 is attenuated




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory