Ptger3^tm1Csml
Targeted Allele Detail

Summary

• Symbol: Ptger3^tm1Csml
• Name: prostaglandin E receptor 3 (subtype EP3); targeted mutation 1, Clifford B Saper
• MGI ID: MGI:3764893
• Synonyms: ptger3^flox
• Gene: Ptger3 Location: Chr3:157272459-157350392 bp, + strand Genetic Position: Chr3, 81.32 cM
• Alliance: Ptger3^tm1Csml page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:127396
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was introduced 70 bp upstream of the translation initiation site and a loxP-frt-Neo/KanR-frt cassette was inserted 408 bp downstream of exon 1. The selectable markers were removed by flp-mediated recombination using transient flp expression. Normal expression patterns in the brain were confirmed by in situ hybridization. (J:127396)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ptger3 Mutation: 17 strains or lines available

References

• Original: J:127396 Lazarus M, et al., EP3 prostaglandin receptors in the median preoptic nucleus are critical for fever responses. Nat Neurosci. 2007 Sep;10(9):1131-3
• All: 11 reference(s)