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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cyp26b1tm1Ptk
targeted mutation 1, Martin Petkovich
MGI:3764691
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Cyp26b1tm1Ptk/Cyp26b1tm1Ptk
Plekha5Tg(AMH-cre)1Flor/Plekha5+ 		involves: 129S2/SvPas * C57BL/6 * SJL MGI:4415047


Genotype
MGI:4415047
cn1
Allelic
Composition		 Cyp26b1tm1Ptk/Cyp26b1tm1Ptk
Plekha5Tg(AMH-cre)1Flor/Plekha5+
Genetic
Background		 involves: 129S2/SvPas * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cyp26b1tm1Ptk mutation (0 available); any Cyp26b1 mutation (35 available)
Plekha5Tg(AMH-cre)1Flor mutation (1 available); any Plekha5 mutation (109 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Loss of germ cells in adult Cyp26b1tm1Ptk/Cyp26b1tm1Ptk Plekha5Tg(AMH-cre)1Flor/0 animals

reproductive system
decreased male germ cell number ( J:154048 )
• fewer germ cells at postnatal day 0 (P0)
• some seminiferous tubules are devoid of germ cells at P0
abnormal seminiferous tubule morphology ( J:154048 )
• some abnormal seminiferous tubules devoid of germ cells in 3-month-old testes
• other tubules contain cells from all stages of spermatogenesis
• numbers of Sertoli cells are unchanged
small seminiferous tubules ( J:154048 )
• reduced diameter of seminiferous tubules lacking germ cells
increased Leydig cell number ( J:154048 )
• Leydig cell hyperplasia outside the seminiferous tubules lacking germ cells
small testis ( J:154048 )
• smaller testes
abnormal spermatogenesis ( J:154048 )
• some germ cells exit from G0 and re-enter mitosis in E16.5
• 22% of the germ cells are Ki67-positive in the testes in E16.5
• no significant difference in the overall number of Ki67-stained somatic cells
abnormal male meiosis ( J:154048 )
• meiotic germ cells are detected in E16.5
• SCP3-positive cells are detected in a subset of tubules

endocrine/exocrine glands
abnormal seminiferous tubule morphology ( J:154048 )
• some abnormal seminiferous tubules devoid of germ cells in 3-month-old testes
• other tubules contain cells from all stages of spermatogenesis
• numbers of Sertoli cells are unchanged
small seminiferous tubules ( J:154048 )
• reduced diameter of seminiferous tubules lacking germ cells
increased Leydig cell number ( J:154048 )
• Leydig cell hyperplasia outside the seminiferous tubules lacking germ cells
small testis ( J:154048 )
• smaller testes

cellular
decreased male germ cell number ( J:154048 )
• fewer germ cells at postnatal day 0 (P0)
• some seminiferous tubules are devoid of germ cells at P0




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory