Phenotypes associated with this allele
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grem1tm1Ecan mutation
(0 available);
any
Grem1 mutation
(16 available)
Grem1tm1Rmh mutation
(1 available);
any
Grem1 mutation
(16 available)
Tg(BGLAP-cre)1Clem mutation
(1 available)
|
|
|
skeleton
|
|
• in vitro osteoblast maturation is enhanced
|
|
|
• 40% increase in trabecular bone volume due to increased bone thickness
|
|
|
• the mineral apposition rate is enhanced
|
|
|
• bone formation rate is 2.5 fold higher than in littermate controls
|
cellular
|
|
• in vitro osteoblast maturation is enhanced
|
embryo
|
|
• the neural tube and brain fail to fuse dorsally unlike in wild-type mice
|
|
|
• mice exhibit disorganized somites compared with wild-type mice
|
|
|
• mice exhibit small somites compared with wild-type mice
|
nervous system
|
|
• the neural tube and brain fail to fuse dorsally unlike in wild-type mice
|
|
|
• development anterior to the midbrain is arrested
|
skeleton
|
|
• mice lack sclerotome compared with wild-type mice
• however, cell death and proliferation is normal
|
limbs/digits/tail
growth/size/body
|
|
• mice exhibit abnormal head development compared with wild-type mice
|
nervous system
|
|
• at E8.5 and E9.5, mice exhibit buckled neural tubes that frequently fail to close anteriorly unlike in wild-type mice
|
|
|
• anteriorly in some mice
|
embryo
|
|
• at E8.5 and E9.5, mice exhibit buckled neural tubes that frequently fail to close anteriorly unlike in wild-type mice
|
|
|
• anteriorly in some mice
|
|
|
• at E8.5 and E9.5, mice exhibit small posterior somites compared with wild-type mice
|
Analysis Tools