Phenotypes associated with this allele
immune system
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• mice have predominance of CD4+CD8- T cells in thymus and periphery, indicating that MHC I-restricted cells are forced to differentiate into CD4+CD8- T cells
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• after TCR stimulation, interferon gamma production is absent from class I-restricted CD4+CD8- cells
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hematopoietic system
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• mice have predominance of CD4+CD8- T cells in thymus and periphery, indicating that MHC I-restricted cells are forced to differentiate into CD4+CD8- T cells
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neoplasm
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• decreased incidence compared to mutant mice wild-type for Runx3
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mortality/aging
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• increased lifespan compared to mutant mice wild-type for Runx3
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skeleton
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• decreased incidence compared to mutant mice wild-type for Runx3
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mortality/aging
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• many die before osteosarcoma formation
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Runx1tm1Toku mutation
(0 available);
any
Runx1 mutation
(35 available)
Runx3tm1Itan mutation
(1 available);
any
Runx3 mutation
(24 available)
Tg(Cd4-cre)1Cwi mutation
(10 available)
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immune system
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• significantly lower than in controls
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hematopoietic system
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• significantly lower than in controls
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Runx3tm1Itan mutation
(1 available);
any
Runx3 mutation
(24 available)
Tg(Cd4-cre)1Cwi mutation
(10 available)
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immune system
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• subset of CD8-positive T cells in the periphery also express intermediate levels of CD4
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• very few CD8-positive T cells are found in the thymus
• level of mature CD8-postive T cells in the thymus reduced by 25%
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• CD8+ T cell absolute numbers are decreased
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• slighlty higher levels in the serum
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• a mild asthma-like disease occurs in one third of the mice with lymphocytes and eosinophils infiltrating the bronchioles and perivascular space
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respiratory system
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• a mild asthma-like disease occurs in one third of the mice with lymphocytes and eosinophils infiltrating the bronchioles and perivascular space
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hematopoietic system
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• subset of CD8-positive T cells in the periphery also express intermediate levels of CD4
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• very few CD8-positive T cells are found in the thymus
• level of mature CD8-postive T cells in the thymus reduced by 25%
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• CD8+ T cell absolute numbers are decreased
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• slighlty higher levels in the serum
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Runx1tm1Toku mutation
(0 available);
any
Runx1 mutation
(35 available)
Runx3tm1Itan mutation
(1 available);
any
Runx3 mutation
(24 available)
Tg(Cd4-cre)1Cwi mutation
(10 available)
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immune system
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• significantly lower than in controls
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hematopoietic system
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• significantly lower than in controls
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immune system
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• very few CD8 T cells found in the thymus
• the CD8 T cells that found have escaped Cre excession
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hematopoietic system
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• very few CD8 T cells found in the thymus
• the CD8 T cells that found have escaped Cre excession
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Runx1tm1Toku mutation
(0 available);
any
Runx1 mutation
(35 available)
Runx3tm1Itan mutation
(1 available);
any
Runx3 mutation
(24 available)
Tg(Cd4-cre)1Cwi mutation
(10 available)
|
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immune system
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• numbers are lower than in controls
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• mice show a marked reduction in CD8+ T cells
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hematopoietic system
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• numbers are lower than in controls
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• mice show a marked reduction in CD8+ T cells
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Analysis Tools