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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Nkx2-1-cre)1Wdr
transgene insertion 1, William D Richardson
MGI:3761164
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Celsr3tm1Agof/Celsr3tm2Agof
Tg(Nkx2-1-cre)1Wdr/0 		involves: 129P2/OlaHsd MGI:3795745
cn2
 		Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Lhx6tm2Vpa/Lhx6tm2Vpa
Tg(Nkx2-1-cre)1Wdr/0 		involves: 129P2/OlaHsd * 129X1/SvJ MGI:5491493
cn3
 		Celsr3tm1Agof/Celsr3tm2Agof
Tg(Gsx2-icre)1Kess/0
Tg(Nkx2-1-cre)1Wdr/0 		involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:3795746


Genotype
MGI:3795745
cn1
Allelic
Composition		 Celsr3tm1Agof/Celsr3tm2Agof
Tg(Nkx2-1-cre)1Wdr/0
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Celsr3tm1Agof mutation (0 available); any Celsr3 mutation (122 available)
Celsr3tm2Agof mutation (0 available); any Celsr3 mutation (122 available)
Tg(Nkx2-1-cre)1Wdr mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:134879 )
N
• the brain internal capsule develops normally




Genotype
MGI:5491493
cn2
Allelic
Composition		 Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Lhx6tm2Vpa/Lhx6tm2Vpa
Tg(Nkx2-1-cre)1Wdr/0
Genetic
Background		 involves: 129P2/OlaHsd * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(EYFP)Cos mutation (11 available); any Gt(ROSA)26Sor mutation (944 available)
Lhx6tm2Vpa mutation (0 available); any Lhx6 mutation (27 available)
Tg(Nkx2-1-cre)1Wdr mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal brain interneuron morphology ( J:196342 )
• mice exhibit impaired somatostatin+ cortical interneuron differentiation compared with control mice




Genotype
MGI:3795746
cn3
Allelic
Composition		 Celsr3tm1Agof/Celsr3tm2Agof
Tg(Gsx2-icre)1Kess/0
Tg(Nkx2-1-cre)1Wdr/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Celsr3tm1Agof mutation (0 available); any Celsr3 mutation (122 available)
Celsr3tm2Agof mutation (0 available); any Celsr3 mutation (122 available)
Tg(Gsx2-icre)1Kess mutation (1 available)
Tg(Nkx2-1-cre)1Wdr mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:134879 )
N
• the brain internal capsule develops normally




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory