All Phenotypes Sufu<Gt(XB699)Byg> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Sufu^Gt(XB699)Byg
gene trap XB699, BayGenomics
MGI:3759455

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sufu^Gt(XB699)Byg/Sufu^Gt(XB699)Byg	involves: 129P2/OlaHsd * C57BL/6	MGI:3759456
cx2	Sufu^Gt(XB699)Byg/Sufu⁺ Trp53^tm1Tyj/Trp53^tm1Tyj	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6	MGI:3759457

Allelic Composition	Sufu^Gt(XB699)Byg/Sufu^Gt(XB699)Byg
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sufu^Gt(XB699)Byg mutation (0 available); any Sufu mutation (59 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:125534 )

• no mice are recovered after E10 due to defects in neural tube closure and heart abnormalities

nervous system

abnormal neural tube closure ( J:125534 )

cardiovascular system

abnormal heart morphology ( J:125534 )

embryo

abnormal neural tube closure ( J:125534 )

Allelic Composition	Sufu^Gt(XB699)Byg/Sufu⁺ Trp53^tm1Tyj/Trp53^tm1Tyj
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sufu^Gt(XB699)Byg mutation (0 available); any Sufu mutation (59 available)
Trp53^tm1Tyj mutation (12 available); any Trp53 mutation (238 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:125534 )

• mice die around 4 months of age compared to Trp53^tm1Tyj homozygotes that survive to 5 months

neoplasm

increased rhabdomyosarcoma incidence ( J:125534 )

• unlike Sufu^GT(XB699)Byg heterozygotes, 5 of 55 mice develop rhabdomyosarcoma

increased lymphoma incidence ( J:125534 )

• unlike Sufu^GT(XB699)Byg heterozygotes, 8 of 55 mice develop lymphomas or thymomas likely due to Trp53^tm1Tyj

increased medulloblastoma incidence ( J:125534 )

• unlike Sufu^GT(XB699)Byg heterozygotes, 32 of 55 mice develop medulloblastomas that express TUBB3 and GFAP and exhibit increased apoptosis

nervous system

increased medulloblastoma incidence ( J:125534 )

• unlike Sufu^GT(XB699)Byg heterozygotes, 32 of 55 mice develop medulloblastomas that express TUBB3 and GFAP and exhibit increased apoptosis

muscle

increased rhabdomyosarcoma incidence ( J:125534 )

• unlike Sufu^GT(XB699)Byg heterozygotes, 5 of 55 mice develop rhabdomyosarcoma

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
medulloblastoma		DOID:0050902	OMIM:155255	J:173443

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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