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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Camk2a-cre/ERT2)2Gsc
transgene insertion 2, Gunther Schutz
MGI:3759305
Summary 8 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Gpx4em1Marc/Gpx4tm2Marc
Tg(Camk2a-cre/ERT2)2Gsc/0 		involves: 129P2/OlaHsd * C57BL/6J * FVB/N MGI:8350560
cn2
 		Nr3c1tm2Gsc/Nr3c1tm2Gsc
Tg(Camk2a-cre/ERT2)2Gsc/0 		involves: 129P2/OlaHsd * FVB/N MGI:3759306
cn3
 		Gpx4tm2Marc/Gpx4tm2Marc
Tg(Camk2a-cre/ERT2)2Gsc/0 		involves: 129P2/OlaHsd * FVB/N MGI:8350567
cn4
 		Gt(ROSA)26Sortm1(Crh)Jde/Gt(ROSA)26Sortm1(Crh)Jde
Tg(Camk2a-cre/ERT2)2Gsc/0 		involves: 129S2/SvPas * C57BL/6J * FVB/N MGI:5294462
cn5
 		Prkcztm1.1Rlh/Prkcztm1.1Rlh
Tg(Camk2a-cre/ERT2)2Gsc/0 		involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL MGI:5485250
cn6
 		Map2k4tm1Ctr/Map2k4tm1Ctr
Map2k7tm1Rjd/Map2k7tm1Rjd
Tg(APPswe,PSEN1dE9)85Dbo/0
Tg(Camk2a-cre/ERT2)2Gsc/0 		involves: C3H * C57BL/6 * FVB/N MGI:5297909
cn7
 		Nae1tm1c(EUCOMM)Wtsi/Nae1tm1c(EUCOMM)Wtsi
Tg(Camk2a-cre/ERT2)2Gsc/0
Tg(Thy1-EGFP)MJrs/0 		involves: C57BL/6J * C57BL/6N * CBA * FVB/N * SJL MGI:6259522
cn8
 		Prox1tm1.1Fuma/Prox1tm1.1Fuma
Tg(Camk2a-cre/ERT2)2Gsc/0 		involves: C57BL/6NCrlj * CBA/JNCrlj * FVB/N MGI:5438959


Genotype
MGI:8350560
cn1
Allelic
Composition		 Gpx4em1Marc/Gpx4tm2Marc
Tg(Camk2a-cre/ERT2)2Gsc/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpx4em1Marc mutation (0 available); any Gpx4 mutation (80 available)
Gpx4tm2Marc mutation (0 available); any Gpx4 mutation (80 available)
Tg(Camk2a-cre/ERT2)2Gsc mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
decreased vertical activity ( J:385850 )
• after tamoxifen administration
decreased locomotor activity ( J:385850 )
• after tamoxifen administration

cellular
increased ferroptosis ( J:385850 )
• cerebral cortex degeneration caused by ferroptosis of neurons

nervous system
decreased cerebral cortex cell number ( J:385850 )
• atrophy after tamoxifen administration
abnormal stratification in cerebral cortex ( J:385850 )
• disorganized after tamoxifen administration
thin cerebral cortex ( J:385850 )
• atrophy after tamoxifen administration




Genotype
MGI:3759306
cn2
Allelic
Composition		 Nr3c1tm2Gsc/Nr3c1tm2Gsc
Tg(Camk2a-cre/ERT2)2Gsc/0
Genetic
Background		 involves: 129P2/OlaHsd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr3c1tm2Gsc mutation (1 available); any Nr3c1 mutation (36 available)
Tg(Camk2a-cre/ERT2)2Gsc mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased circulating corticosterone level ( J:125230 )
• when treated with tamoxifen the level of serum corticosterone is increased to 39+/-8 ng/ml when one copies of the transgene is present, 100+/-20 ng/ml when two copies of the transgene are present and 108+/-19 ng/ml when four copies of the transgene are present compared to 13+/-5 ng/ml in wild-type




Genotype
MGI:8350567
cn3
Allelic
Composition		 Gpx4tm2Marc/Gpx4tm2Marc
Tg(Camk2a-cre/ERT2)2Gsc/0
Genetic
Background		 involves: 129P2/OlaHsd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpx4tm2Marc mutation (0 available); any Gpx4 mutation (80 available)
Tg(Camk2a-cre/ERT2)2Gsc mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
decreased vertical activity ( J:385850 )
• after tamoxifen administration
decreased locomotor activity ( J:385850 )
• after tamoxifen administration

cellular
astrocytosis ( J:385850 )
• in cerebral cortex from 1 week after tamoxifen administration
microgliosis ( J:385850 )
• in cerebral cortex from 2 weeks after tamoxifen administration
increased ferroptosis ( J:385850 )
• cerebral cortex degeneration caused by ferroptosis of neurons

hematopoietic system
microgliosis ( J:385850 )
• in cerebral cortex from 2 weeks after tamoxifen administration

immune system
microgliosis ( J:385850 )
• in cerebral cortex from 2 weeks after tamoxifen administration

nervous system
astrocytosis ( J:385850 )
• in cerebral cortex from 1 week after tamoxifen administration
microgliosis ( J:385850 )
• in cerebral cortex from 2 weeks after tamoxifen administration
decreased cerebral cortex cell number ( J:385850 )
• atrophy after tamoxifen administration
abnormal stratification in cerebral cortex ( J:385850 )
• disorganized after tamoxifen administration
thin cerebral cortex ( J:385850 )
• atrophy after tamoxifen administration




Genotype
MGI:5294462
cn4
Allelic
Composition		 Gt(ROSA)26Sortm1(Crh)Jde/Gt(ROSA)26Sortm1(Crh)Jde
Tg(Camk2a-cre/ERT2)2Gsc/0
Genetic
Background		 involves: 129S2/SvPas * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(Crh)Jde mutation (0 available); any Gt(ROSA)26Sor mutation (1211 available)
Tg(Camk2a-cre/ERT2)2Gsc mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
increased anxiety-related response ( J:176339 )
• in tamoxifen-treated mice during a dark-light box and elevated plus-maze




Genotype
MGI:5485250
cn5
Allelic
Composition		 Prkcztm1.1Rlh/Prkcztm1.1Rlh
Tg(Camk2a-cre/ERT2)2Gsc/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkcztm1.1Rlh mutation (1 available); any Prkcz mutation (42 available)
Tg(Camk2a-cre/ERT2)2Gsc mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:194557 )
N
• mice exhibit normal theta burst and high frequency stimulation of long term potentiation




Genotype
MGI:5297909
cn6
Allelic
Composition		 Map2k4tm1Ctr/Map2k4tm1Ctr
Map2k7tm1Rjd/Map2k7tm1Rjd
Tg(APPswe,PSEN1dE9)85Dbo/0
Tg(Camk2a-cre/ERT2)2Gsc/0
Genetic
Background		 involves: C3H * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map2k4tm1Ctr mutation (0 available); any Map2k4 mutation (30 available)
Map2k7tm1Rjd mutation (0 available); any Map2k7 mutation (20 available)
Tg(APPswe,PSEN1dE9)85Dbo mutation (8 available)
Tg(Camk2a-cre/ERT2)2Gsc mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
amyloid beta deposits ( J:178060 )
• tamoxifen-treated mice develop fewer plaques than control mice expressing Tg(APPswe,PSEN1dE9)85Dbo
abnormal neurite morphology ( J:178060 )
• tamoxifen-treated mice exhibit fewer dystrophic neurite clusters and few isolated neurites with residual bodies compared with control mice expressing Tg(APPswe,PSEN1dE9)85Dbo

homeostasis/metabolism
amyloid beta deposits ( J:178060 )
• tamoxifen-treated mice develop fewer plaques than control mice expressing Tg(APPswe,PSEN1dE9)85Dbo




Genotype
MGI:6259522
cn7
Allelic
Composition		 Nae1tm1c(EUCOMM)Wtsi/Nae1tm1c(EUCOMM)Wtsi
Tg(Camk2a-cre/ERT2)2Gsc/0
Tg(Thy1-EGFP)MJrs/0
Genetic
Background		 involves: C57BL/6J * C57BL/6N * CBA * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nae1tm1c(EUCOMM)Wtsi mutation (0 available); any Nae1 mutation (34 available)
Tg(Camk2a-cre/ERT2)2Gsc mutation (1 available)
Tg(Thy1-EGFP)MJrs mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
behavior/neurological phenotype ( J:262411 )
N
• mice exhibit normal locomotion, sociability, fear conditioning and anxiety related behaviors
impaired long-term object recognition memory ( J:262411 )
• impaired in tamoxifen-treated mice
impaired short-term object recognition memory ( J:262411 )
• impaired in tamoxifen-treated mice
abnormal spatial working memory ( J:262411 )
• tamoxifen-treated mice exhibit impaired performance in a water-cross maze and Y-maze

nervous system
abnormal dendritic spine morphology ( J:262411 )
• reduced size in the cortical and hippocampal pyramidal neurons of tamoxifen-treated mice
• however, general neuron morphology is normal
decreased dendritic spine density ( J:262411 )
• in the cortical and hippocampal pyramidal neurons of tamoxifen-treated mice
abnormal CNS synaptic transmission ( J:262411 )
• reduced in tamoxifen-treated mice
• however, excitability is normal




Genotype
MGI:5438959
cn8
Allelic
Composition		 Prox1tm1.1Fuma/Prox1tm1.1Fuma
Tg(Camk2a-cre/ERT2)2Gsc/0
Genetic
Background		 involves: C57BL/6NCrlj * CBA/JNCrlj * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prox1tm1.1Fuma mutation (0 available); any Prox1 mutation (49 available)
Tg(Camk2a-cre/ERT2)2Gsc mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal dentate gyrus morphology ( J:187615 )
• at P28, mice treated with tamoxifen during neonatal development exhibit loss of Prox1 expression in most dentate gyrus cells and both mature and immature granule cell properties and intermingled dentate gyrus progenitors in the granular layer unlike control mice
abnormal hippocampus CA4 region morphology ( J:187615 )
• at P28, mossy cells are reduced in the hilus compared to in control mice
abnormal hippocampus granule cell morphology ( J:187615 )
• at P28, mice treated with tamoxifen during neonatal development exhibit loss of Prox1 expression in most dentate gyrus cells and both mature and immature granule cell properties unlike control mice




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Send questions and comments to User Support. 		last database update
06/09/2026
MGI 6.24 		The Jackson Laboratory