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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Megf8hlb611
heart, lung and blood 611
MGI:3722325
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Megf8hlb611/Megf8hlb611 involves: C57BL/6J MGI:3839105
hm2
Megf8hlb611/Megf8hlb611 involves: C57BL/6J * C3H/HeJ MGI:3839106
cx3
Megf8hlb611/Megf8hlb611
Mosmoem1Rroh/Mosmoem1Rroh
involves: C57BL/6 * C57BL/6J MGI:6782870


Genotype
MGI:3839105
hm1
Allelic
Composition
Megf8hlb611/Megf8hlb611
Genetic
Background
involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Megf8hlb611 mutation (0 available); any Megf8 mutation (96 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Left-right asymmetric defects in Megf8hlb611/Megf8hlb611 embryos

cardiovascular system
• the outflow tract is shortened compared to in wild-type mice
• 100% of E13.5-E14.5 mutants exhibit transposition of the great arteries (J:311933)
• mice exhibit abnormal pulmonary venous connections
• 67% of E13.5-E14.5 mutants exhibit abnormal cardiac apex; mesocardiac or dextrocardia
• in some mice (J:146805)
• in some mice (J:146805)
• 100% of E13.5-E14.5 mutants exhibit cardiac septum defects, either ventricular septal defect or atrioventricular septal defect

limbs/digits/tail
• 100% of E13.5-E14.5 mutants exhibit preaxial digit duplication

hematopoietic system
N
• erythropoiesis is normal
• in some mice
• in some mice

embryo
N
• despite heterotaxia, mice exhibit normal nodal cilia rotation

digestive/alimentary system
• right-sided stomach

respiratory system
• 92% of E13.5-E14.5 mutants exhibit abnormal lung situs

growth/size/body
• 100% of of E13.5-E14.5 mutants exhibit heterotaxy and situs inversus (J:311933)
• right-sided stomach
• 67% of E13.5-E14.5 mutants exhibit abnormal abdomen situs
• 92% of E13.5-E14.5 mutants exhibit abnormal lung situs
• 100% of of E13.5-E14.5 mutants exhibit heterotaxy and situs inversus

immune system
• in some mice
• in some mice




Genotype
MGI:3839106
hm2
Allelic
Composition
Megf8hlb611/Megf8hlb611
Genetic
Background
involves: C57BL/6J * C3H/HeJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Megf8hlb611 mutation (0 available); any Megf8 mutation (96 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• in some mice
• in the small ventricle where the trabecula septomarginalis is missing
• anterior positioning of the aorta
• 6 of 10 mice exhibit anomalous pulmonary venous connection
• in 3 of 10 mice
• in 4 of 10 mice
• with the left and right superior vena cava inserted into the anatomic left and right atria
• mice exhibit a dominant left ventricle with varied situs unlike in wild-type mice

growth/size/body
• thoracic and abdominal cavity organs exhibit situs abnormalities
• however, mice exhibit normal nodal ciliary function

immune system
• in some mice
• in some mice

renal/urinary system

digestive/alimentary system
• the stomach can be found on the right or left side of the body unlike in wild-type mice
• stomach of one mouse exhibited bilateral symmetry unlike in wild-type mice

limbs/digits/tail
• on all four limbs

liver/biliary system
• mice have symmetrical bilobed livers unlike in wild-type mice

muscle
• in the small ventricle where the trabecula septomarginalis is missing

respiratory system

hematopoietic system
• in some mice
• in some mice




Genotype
MGI:6782870
cx3
Allelic
Composition
Megf8hlb611/Megf8hlb611
Mosmoem1Rroh/Mosmoem1Rroh
Genetic
Background
involves: C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Megf8hlb611 mutation (0 available); any Megf8 mutation (96 available)
Mosmoem1Rroh mutation (0 available); any Mosmo mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• 20% of E13.5-E14.5 mutants exhibit double outlet right ventricle
• 60% of E13.5-E14.5 mutants exhibit transposition of the great arteries
• 100% of E13.5-E14.5 mutants exhibit abnormal cardiac apex; mesocardia or dextrocardia
• 100% of E13.5-E14.5 mutants exhibit cardiac septum defects, either ventricular septal defect or atrioventricular septal defect
• 20% of E13.5-E14.5 mutants exhibit persistent truncus arteriosus

growth/size/body
• 100% of of E13.5-E14.5 mutants exhibit heterotaxy and situs inversus
• 80% of E13.5-E14.5 mutants exhibit abnormal abdomen situs
• 100% of E13.5-E14.5 mutants exhibit abnormal lung situs
• 100% of of E13.5-E14.5 mutants exhibit heterotaxy and situs inversus

limbs/digits/tail
• 100% of E13.5-E14.5 mutants exhibit preaxial digit duplication

respiratory system
• 100% of E13.5-E14.5 mutants exhibit abnormal lung situs





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last database update
04/30/2024
MGI 6.23
The Jackson Laboratory