Phenotypes associated with this allele

• Allele Symbol: Traf3^tm1Bshp
• Allele Name: targeted mutation 1, Gail A Bishop
• Allele ID: MGI:3722126
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Traf3^tm1Bshp/Traf3^tm1Bshp Cd19^tm1(cre)Cgn/Cd19^+	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL	MGI:3722773

Genotype
MGI:3722773

cn1

• Allelic Composition: Traf3^tm1Bshp/Traf3^tm1Bshp; Cd19^tm1(cre)Cgn/Cd19⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal leukocyte morphology ( J:124329 )

increased B cell number ( J:124329 )

• B cell numbers are increased in adult spleen and lymph nodes

• the number of T2 transitional, follicular and marginal zone B cells is increased in the spleen

increased transitional stage B cell number ( J:124329 )

• the number of T2 transitional B cells is increased in the spleen

• the number of T1 transitional B cells in slightly increased (1.4-fold)

increased follicular B cell number ( J:124329 )

increased marginal zone B cell number ( J:124329 )

• the percent and number of marginal zone B cells is increased

decreased T cell number ( J:124329 )

• in adult mice

abnormal immune system organ morphology ( J:124329 )

enlarged spleen ( J:124329 )

• adult mice have splenomegaly

abnormal spleen germinal center morphology ( J:124329 )

• spontaneous germinal centers form

increased spleen white pulp amount ( J:124329 )

• white pulp is enlarged

abnormal lymph node B cell domain morphology ( J:124329 )

• adult mice have an increased in the size and number of lymphoid follicles

enlarged lymph nodes ( J:124329 )

• adult mice have enlarged lymph nodes

abnormal immune system physiology ( J:124329 )

abnormal adaptive immunity ( J:124329 )

• when challenged with TNP-Ficoll, mice generate higher titers of TNO-specific IgM, igG1, IgG2a, IgG2b, and IgG3 compared to wild-type mice

• when challenged with T dependent antigen (TNP-KLH), mice only show an increase in TNP-specific IgM response

• the T-I antibody response in increased while the T-D IgG1 response is normal

decreased B cell apoptosis ( J:124329 )

• unstimulated ex vivo B cell survive longer than for wild-type B cells with 30% of B cells alive after 16 days in culture when control cells were no longer alive

• B cell activating factor did not enhance ex vivo survival

• B cell do not undergo apoptosis ex vivo as wild-type B cells do

increased IgA level ( J:124329 )

• serum IgA is elevated 2- to 5-fold

increased IgG level ( J:124329 )

• germinal center B cells express more surface IgG

• serum IgG2a, IgG2b and IgG3 are elevated 2- to 5-fold

increased IgG2a level ( J:124329 )

increased IgG2b level ( J:124329 )

increased IgG3 level ( J:124329 )

increased IgM level ( J:124329 )

• germinal center B cells express more surface IgM

• serum IgM is elevated 2- to 5-fold

autoimmune response ( J:124329 )

• mice display autoimmune manifestations such as double stranded DNA antibodies and the presence of lymphocyte infiltrate in the kidney and liver

increased anti-double stranded DNA antibody level ( J:124329 )

• in 80% of mice

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:124329 )

• mice do not exhibit a reduction in spleen weight or depletion of B cells in response to administration of TACI-Ig (an inhibitor or B cell activating factor and a proliferation-inducing ligand)

liver/biliary system

abnormal liver morphology ( J:124329 )

• 3 of 4 mice contain lymphocyte infiltration at multiple locations in the kidney and liver

renal/urinary system

abnormal kidney morphology ( J:124329 )

• 3 of 4 mice contain lymphocyte infiltration at multiple locations in the kidney and liver

hematopoietic system

decreased B cell apoptosis ( J:124329 )

• unstimulated ex vivo B cell survive longer than for wild-type B cells with 30% of B cells alive after 16 days in culture when control cells were no longer alive

• B cell activating factor did not enhance ex vivo survival

• B cell do not undergo apoptosis ex vivo as wild-type B cells do

enlarged spleen ( J:124329 )

• adult mice have splenomegaly

abnormal leukocyte morphology ( J:124329 )

increased B cell number ( J:124329 )

• B cell numbers are increased in adult spleen and lymph nodes

• the number of T2 transitional, follicular and marginal zone B cells is increased in the spleen

increased transitional stage B cell number ( J:124329 )

• the number of T2 transitional B cells is increased in the spleen

• the number of T1 transitional B cells in slightly increased (1.4-fold)

increased follicular B cell number ( J:124329 )

increased marginal zone B cell number ( J:124329 )

• the percent and number of marginal zone B cells is increased

decreased T cell number ( J:124329 )

• in adult mice

abnormal spleen germinal center morphology ( J:124329 )

• spontaneous germinal centers form

increased spleen white pulp amount ( J:124329 )

• white pulp is enlarged

increased IgA level ( J:124329 )

• serum IgA is elevated 2- to 5-fold

increased IgG level ( J:124329 )

• germinal center B cells express more surface IgG

• serum IgG2a, IgG2b and IgG3 are elevated 2- to 5-fold

increased IgG2a level ( J:124329 )

increased IgG2b level ( J:124329 )

increased IgG3 level ( J:124329 )

increased IgM level ( J:124329 )

• germinal center B cells express more surface IgM

• serum IgM is elevated 2- to 5-fold

cellular

decreased B cell apoptosis ( J:124329 )

• unstimulated ex vivo B cell survive longer than for wild-type B cells with 30% of B cells alive after 16 days in culture when control cells were no longer alive

• B cell activating factor did not enhance ex vivo survival

• B cell do not undergo apoptosis ex vivo as wild-type B cells do

growth/size/body

enlarged spleen ( J:124329 )

• adult mice have splenomegaly