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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gli3Mos1
modifier of Sox10 1
MGI:3720956
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gli3Mos1/Gli3Mos1 involves: BALB/cJ * C57BL/6J MGI:3797119
ht2
 		Gli3Mos1/Gli3+ involves: BALB/cJ * C57BL/6J MGI:3797122
ht3
 		Gli3Mos1/Gli3Xt-J involves: BALB/cJ * C3H/HeJ * C57BL/6J MGI:3797118
cx4
 		Gli3Mos1/Gli3+
Sox10tm1Weg/Sox10+ 		involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J MGI:3797124
cx5
 		Gli3Mos1/Gli3Mos1
Tg(Dct-lacZ)A12Jkn/0 		involves: BALB/cJ * C57BL/6 * C57BL/6J * CBA MGI:3797121
cx6
 		Gli3Mos1/Gli3+
Tg(Dct-lacZ)A12Jkn/0 		involves: BALB/cJ * C57BL/6 * C57BL/6J * CBA MGI:3797120


Genotype
MGI:3797119
hm1
Allelic
Composition		 Gli3Mos1/Gli3Mos1
Genetic
Background		 involves: BALB/cJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli3Mos1 mutation (0 available); any Gli3 mutation (80 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

embryo
abnormal melanoblast morphology ( J:136642 )
• at E11.5, mice exhibit fewer melanoblasts in the mid-trunk compared to in wild-type mice
• however, melanoblasts differentiate in vitro

nervous system
abnormal melanoblast morphology ( J:136642 )
• at E11.5, mice exhibit fewer melanoblasts in the mid-trunk compared to in wild-type mice
• however, melanoblasts differentiate in vitro




Genotype
MGI:3797122
ht2
Allelic
Composition		 Gli3Mos1/Gli3+
Genetic
Background		 involves: BALB/cJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli3Mos1 mutation (0 available); any Gli3 mutation (80 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
belly spot ( J:136642 )
• mice exhibit a ventral hypopigmented patch
hypopigmentation ( J:136642 )
• 37.7% of mice exhibit ventral hypopigmentation
• however, melanoblasts differentiate in vitro

integument
belly spot ( J:136642 )
• mice exhibit a ventral hypopigmented patch




Genotype
MGI:3797118
ht3
Allelic
Composition		 Gli3Mos1/Gli3Xt-J
Genetic
Background		 involves: BALB/cJ * C3H/HeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli3Mos1 mutation (0 available); any Gli3 mutation (80 available)
Gli3Xt-J mutation (3 available); any Gli3 mutation (80 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality ( J:136642 )
• no mice are recovered at weaning




Genotype
MGI:3797124
cx4
Allelic
Composition		 Gli3Mos1/Gli3+
Sox10tm1Weg/Sox10+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli3Mos1 mutation (0 available); any Gli3 mutation (80 available)
Sox10tm1Weg mutation (1 available); any Sox10 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
belted ( J:136642 )
• mice exhibit an increased penetrance and severity of hypopigmentation compared to Sox10tm1Weg heterozygotes with ventral hypopigmentation that often extends onto the dorsal surface forming a belt in the lumbar region
belly spot ( J:136642 )
• mice exhibit ventral hypopigmentation
hypopigmentation ( J:136642 )
• mice exhibit an increased penetrance and severity of hypopigmentation compared to Sox10tm1Weg heterozygotes with ventral hypopigmentation that often extends onto the dorsal surface forming a belt in the lumbar region
• mice exhibit more hypopigmentation than in either single heterozygote

integument
belted ( J:136642 )
• mice exhibit an increased penetrance and severity of hypopigmentation compared to Sox10tm1Weg heterozygotes with ventral hypopigmentation that often extends onto the dorsal surface forming a belt in the lumbar region
belly spot ( J:136642 )
• mice exhibit ventral hypopigmentation




Genotype
MGI:3797121
cx5
Allelic
Composition		 Gli3Mos1/Gli3Mos1
Tg(Dct-lacZ)A12Jkn/0
Genetic
Background		 involves: BALB/cJ * C57BL/6 * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli3Mos1 mutation (0 available); any Gli3 mutation (80 available)
Tg(Dct-lacZ)A12Jkn mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal melanoblast morphology ( J:136642 )
• at E11.5, E14 and E16, mice exhibit fewer melanoblasts in the mid-trunk compared to in wild-type mice
abnormal telencephalon development ( J:136642 )
• the loss of transgene expression in the dorsal telecephalon is attributed to telecephalon ventralization

embryo
abnormal melanoblast morphology ( J:136642 )
• at E11.5, E14 and E16, mice exhibit fewer melanoblasts in the mid-trunk compared to in wild-type mice




Genotype
MGI:3797120
cx6
Allelic
Composition		 Gli3Mos1/Gli3+
Tg(Dct-lacZ)A12Jkn/0
Genetic
Background		 involves: BALB/cJ * C57BL/6 * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli3Mos1 mutation (0 available); any Gli3 mutation (80 available)
Tg(Dct-lacZ)A12Jkn mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
abnormal melanoblast morphology ( J:136642 )
• at E16, mice exhibit a small ventral patch devoid of melanoblasts in the mid-trunk unlike in wild-type mice

nervous system
abnormal melanoblast morphology ( J:136642 )
• at E16, mice exhibit a small ventral patch devoid of melanoblasts in the mid-trunk unlike in wild-type mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory