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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Esrrbtm1.2Nat
targeted mutation 1.2, Jeremy Nathans
MGI:3720482
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Esrrbtm1.2Nat/Esrrbtm1.2Nat involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL MGI:3723506
cn2
 		Esrrbtm1.1Nat/Esrrbtm1.2Nat
Edil3Tg(Sox2-cre)1Amc/Edil3+ 		involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL MGI:3723508
cn3
 		Esrrbtm1.1Nat/Esrrbtm1.2Nat
Tg(Nes-cre)1Kln/0 		involves: 129S6/SvEvTac * C57BL/6 * SJL MGI:3723507


Genotype
MGI:3723506
hm1
Allelic
Composition		 Esrrbtm1.2Nat/Esrrbtm1.2Nat
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Esrrbtm1.2Nat mutation (0 available); any Esrrb mutation (212 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:124941 )
• no homozygous progeny are derived from Esrrbtm1.2 heterozygous matings




Genotype
MGI:3723508
cn2
Allelic
Composition		 Esrrbtm1.1Nat/Esrrbtm1.2Nat
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (44 available)
Esrrbtm1.1Nat mutation (1 available); any Esrrb mutation (212 available)
Esrrbtm1.2Nat mutation (0 available); any Esrrb mutation (212 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
absent startle reflex ( J:124941 )
• no auditory startle reflex
head bobbing ( J:124941 )
• observed beginning at several weeks of age
circling ( J:124941 )
• adults spin or run in circles

hearing/vestibular/ear
abnormal scala media morphology ( J:124941 )
• collapsed at 7 days of age
small scala media ( J:124941 )
• reduction in volume seen at 4 days of age
abnormal semicircular canal morphology ( J:124941 )
• narrowing of membranous labyrinths of the three semicircular canals is observed in postnatal animals
abnormal semicircular canal ampulla morphology ( J:124941 )
• flattening of ampullae is observed postnatally




Genotype
MGI:3723507
cn3
Allelic
Composition		 Esrrbtm1.1Nat/Esrrbtm1.2Nat
Tg(Nes-cre)1Kln/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Esrrbtm1.1Nat mutation (1 available); any Esrrb mutation (212 available)
Esrrbtm1.2Nat mutation (0 available); any Esrrb mutation (212 available)
Tg(Nes-cre)1Kln mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
absent strial marginal cells ( J:124941 )
• loss of strial margenial cells in mutants is observed; this leads to loss of intraepithelial capillaries
increased or absent threshold for auditory brainstem response ( J:124941 )
• ABR thresholds are variably elevated between 1 and 3 months of age




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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory