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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Lhx1tm4Bhr
targeted mutation 4, Richard R Behringer
MGI:3719681
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Lhx1tm4Bhr/Lhx1tm4Bhr
Tg(Nes-cre)1Kln/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL MGI:3719686
cn2
 		Lhx1tm1Tmj/Lhx1tm4Bhr
Lhx5tm1Lmgd/Lhx5tm1Lmgd
Tg(Nes-cre)1Kln/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL MGI:3719689


Genotype
MGI:3719686
cn1
Allelic
Composition		 Lhx1tm4Bhr/Lhx1tm4Bhr
Tg(Nes-cre)1Kln/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lhx1tm4Bhr mutation (0 available); any Lhx1 mutation (21 available)
Tg(Nes-cre)1Kln mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:3719689
cn2
Allelic
Composition		 Lhx1tm1Tmj/Lhx1tm4Bhr
Lhx5tm1Lmgd/Lhx5tm1Lmgd
Tg(Nes-cre)1Kln/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lhx1tm1Tmj mutation (0 available); any Lhx1 mutation (21 available)
Lhx1tm4Bhr mutation (0 available); any Lhx1 mutation (21 available)
Lhx5tm1Lmgd mutation (0 available); any Lhx5 mutation (19 available)
Tg(Nes-cre)1Kln mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
absent cerebellar foliation ( J:123471 )
• absent at E18.5
decreased Purkinje cell number ( J:123471 )
• largely absent at E18.5
• however, granule cells are specified properly
absent Purkinje cell layer ( J:123471 )
• layer is absent at E18.5
small cerebellum ( J:123471 )
• small at E14.5 and E18.5 compared to controls (mice with at least 1 wild-type allele)




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory