All Phenotypes Mef2c<tm2Eno> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mef2c^tm2Eno
targeted mutation 2, Eric N Olson
MGI:3718323

Summary

7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ighg1^tm1(cre)Cgn/0 Mef2c^tm2Eno/Mef2c^tm2Eno	involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6	MGI:6401159
cn2	Ighg1^tm1(cre)Cgn/0 Mef2b^tm1.1Rdf/Mef2b^tm1.1Rdf Mef2c^tm2Eno/Mef2c^tm2Eno	involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6	MGI:6401163
cn3	Mef2c^tm1Eno/Mef2c^tm2Eno Tg(Myog-cre)1Eno/0	involves: 129S/SvEv * 129S7/SvEvBrd	MGI:4418148
cn4	Mef2c^tm1Eno/Mef2c^tm2Eno Twist2^tm1(cre)Dor/Twist2⁺	involves: 129S/SvEv * 129S7/SvEvBrd * 129X1/SvJ	MGI:3719010
cn5	Mef2c^tm1Eno/Mef2c^tm2Eno Tg(Col2a1-cre)1Bhr/0	involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * SJL	MGI:3719016
cn6	Mef2a^tm1.1Limm/Mef2a^tm1.1Limm Mef2c^tm2Eno/Mef2c^tm2Eno Mef2d^tm3Eno/Mef2d^tm3Eno Tg(GFAP-cre)25Mes/0	involves: 129S/SvEv * C57BL/6 * FVB/N	MGI:5560657
cn7	Mef2c^tm2Eno/Mef2c^tm2Eno Mef2d^tm1Eno/Mef2d^tm1Eno Tg(Col2a1-cre)1Bhr/0	involves: 129S/SvEv * C57BL/6 * SJL	MGI:3719017

Allelic Composition	Ighg1^tm1(cre)Cgn/0 Mef2c^tm2Eno/Mef2c^tm2Eno
Genetic Background	involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighg1^tm1(cre)Cgn mutation (3 available); any Ighg1 mutation (28 available)
Mef2c^tm2Eno mutation (0 available); any Mef2c mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased germinal center B cell number ( J:265465 )

• 14 days after immunization with sheep red blood cells (SRBCs)

immune system

decreased germinal center B cell number ( J:265465 )

• 14 days after immunization with sheep red blood cells (SRBCs)

Allelic Composition	Ighg1^tm1(cre)Cgn/0 Mef2b^tm1.1Rdf/Mef2b^tm1.1Rdf Mef2c^tm2Eno/Mef2c^tm2Eno
Genetic Background	involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighg1^tm1(cre)Cgn mutation (3 available); any Ighg1 mutation (28 available)
Mef2b^tm1.1Rdf mutation (0 available); any Mef2b mutation (22 available)
Mef2c^tm2Eno mutation (0 available); any Mef2c mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased germinal center B cell number ( J:265465 )

• 14 days after immunization with sheep red blood cells (SRBCs)

immune system

decreased germinal center B cell number ( J:265465 )

• 14 days after immunization with sheep red blood cells (SRBCs)

Allelic Composition	Mef2c^tm1Eno/Mef2c^tm2Eno Tg(Myog-cre)1Eno/0
Genetic Background	involves: 129S/SvEv * 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mef2c^tm1Eno mutation (0 available); any Mef2c mutation (33 available)
Mef2c^tm2Eno mutation (0 available); any Mef2c mutation (33 available)
Tg(Myog-cre)1Eno mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

abnormal skeletal muscle fiber type ratio ( J:127416 )

• reduction in slow fibers within the soleus

• loss of type I fibers in the gastrocnemius and plantaris muscles and a decrease in number and intensity of type I fibers in the soleus

Allelic Composition	Mef2c^tm1Eno/Mef2c^tm2Eno Twist2^tm1(cre)Dor/Twist2⁺
Genetic Background	involves: 129S/SvEv * 129S7/SvEvBrd * 129X1/SvJ

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:119152 )

• none survive beyond the first week of life

respiratory system

respiratory distress ( J:119152 )

• some mutants have difficulty breathing, evidenced by gasping and accumulation of air in the intestines

skeleton

short fibula ( J:119152 )

• truncation of the fibula is severe

short tibia ( J:119152 )

• truncation of the tibia is severe

abnormal trabecular bone morphology ( J:119152 )

• sternum and radius show completely absence of trabeculated bone

abnormal endochondral bone ossification ( J:119152 )

• mutants exhibit severe defects in ossification on nearly all endochondral bones, especially in the sternum

• ossification of the bone collar appears disorganized

• defects in endochondral ossification result from a failure of chondrocyte hypertrophy

failure of endochondral bone ossification ( J:119152 )

• vertebral bodies and the supraoccipital bone fail to ossify and many phalangeal bones of the digits lack ossification

limbs/digits/tail

short fibula ( J:119152 )

• truncation of the fibula is severe

short tibia ( J:119152 )

• truncation of the tibia is severe

short limbs ( J:119152 )

Allelic Composition	Mef2c^tm1Eno/Mef2c^tm2Eno Tg(Col2a1-cre)1Bhr/0
Genetic Background	involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

decreased length of long bones ( J:119152 )

• truncation of all long bones of the limbs

abnormal endochondral bone ossification ( J:119152 )

• structures of the distal ribs, radii, and sternabrae are distorted by disorganized cartilaginous remnants of the growth plate and aberrant ossification

failure of sternum ossification ( J:119152 )

• absence of ossification of the sternum and a failure in chondrocyte hypertrophy

behavior/neurological

abnormal gait ( J:119152 )

• waddling gait due to shortened limbs

limbs/digits/tail

short limbs ( J:119152 )

• truncation of all long bones of the limbs

Allelic Composition	Mef2a^tm1.1Limm/Mef2a^tm1.1Limm Mef2c^tm2Eno/Mef2c^tm2Eno Mef2d^tm3Eno/Mef2d^tm3Eno Tg(GFAP-cre)25Mes/0
Genetic Background	involves: 129S/SvEv * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mef2a^tm1.1Limm mutation (0 available); any Mef2a mutation (36 available)
Mef2c^tm2Eno mutation (0 available); any Mef2c mutation (33 available)
Mef2d^tm3Eno mutation (0 available); any Mef2d mutation (64 available)
Tg(GFAP-cre)25Mes mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:207812 )

• partial lethality by 5 weeks

nervous system

nervous system phenotype ( J:207812 )

N	• mice exhibit normal numbers of spines per length of dendrite in pyramidal neurons

increased neuron apoptosis ( J:207812 )

• 5-fold

decreased brain size ( J:207812 )

abnormal long-term potentiation ( J:207812 )

• mice exhibit decreased input-output curve compared with wild-type mice

• however, long term potentiation is normal

enhanced paired-pulse facilitation ( J:207812 )

growth/size/body

decreased body weight ( J:207812 )

cellular

increased neuron apoptosis ( J:207812 )

• 5-fold

Allelic Composition	Mef2c^tm2Eno/Mef2c^tm2Eno Mef2d^tm1Eno/Mef2d^tm1Eno Tg(Col2a1-cre)1Bhr/0
Genetic Background	involves: 129S/SvEv * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mef2c^tm2Eno mutation (0 available); any Mef2c mutation (33 available)
Mef2d^tm1Eno mutation (0 available); any Mef2d mutation (64 available)
Tg(Col2a1-cre)1Bhr mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

failure of endochondral bone ossification ( J:119152 )

• nearly all mineralized endochondral skeletons are missing

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