All Phenotypes Tg(Nes-cre)1Nogu MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(Nes-cre)1Nogu
transgene insertion 1, Shigeru Noguchi
MGI:3718108

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Pdgfrb^tm1Msas/Pdgfrb^tm1Msas Tg(Nes-cre)1Nogu/0	B6J.Cg-Pdgfrb^tm1Msas Tg(Nes-cre)1Nogu	MGI:5790635
cn2	Pdgfrb^tm1Msas/Pdgfrb^tm1Msas Tg(Nes-cre)1Nogu/?	involves: 129 * C57BL/6	MGI:3717562
cn3	Pdgfrb^tm2Msas/Pdgfrb^tm2Msas Tg(Nes-cre)1Nogu/?	involves: 129 * C57BL/6	MGI:3717563
cn4	Npvf^tm1.1Ubu/Npvf^tm1.1Ubu Tg(Nes-cre)1Nogu/0	involves: C57BL/6	MGI:7622051

Allelic Composition	Pdgfrb^tm1Msas/Pdgfrb^tm1Msas Tg(Nes-cre)1Nogu/0
Genetic Background	B6J.Cg-Pdgfrb^tm1Msas Tg(Nes-cre)1Nogu

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdgfrb^tm1Msas mutation (0 available); any Pdgfrb mutation (84 available)
Tg(Nes-cre)1Nogu mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal social investigation ( J:229179 )

• mice exhibit social interaction deficits, showing increased non-affiliate behavior (leaving), and decreased active social contact and passive social contact compared to controls

• treatment with the drug T-817MA ameliorates these social behavior deficits

nervous system

decreased neuron number ( J:229179 )

• mice show reduced density of parvalbumin-immunoreactive neurons in the medical prefrontal cortex, hippocampus, amygdala, and superior colliculus

• treatment with the drug T-817MA restores the number of parvalbumin+ neurons

abnormal nervous system electrophysiology ( J:229179 )

• mice exhibit a reduction in auditory phase-locked gamma oscillations

• treatment with the drug T-817MA restores regular phase-locked gamma oscillations

reduced sensorimotor gating ( J:229179 )

• mice show deficits in sensorimotor gating

• treatment with the drug T-817MA ameliorates sensorimotor gating defects

decreased prepulse inhibition ( J:229179 )

• mice show deficits in prepulse inhibition

• treatment with the drug T-817MA ameliorates sensorimotor gating defects

Mouse Models of Human Disease	DO ID	OMIM ID(s)	Ref(s)
autism spectrum disorder	DOID:0060041		J:229179
schizophrenia	DOID:5419	OMIM:181500	J:229179

Allelic Composition	Pdgfrb^tm1Msas/Pdgfrb^tm1Msas Tg(Nes-cre)1Nogu/?
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdgfrb^tm1Msas mutation (0 available); any Pdgfrb mutation (84 available)
Tg(Nes-cre)1Nogu mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased susceptibility to neuronal excitotoxicity ( J:110616 )

• following injection of NMDA, the volume of neuron apoptosis damage caused by excitotoxicity is increased compared to in wild-type mice

abnormal response to injury ( J:110616 )

• damage to the brain measured by TCC staining is increased following cryogenic injury

nervous system

increased susceptibility to neuronal excitotoxicity ( J:110616 )

• following injection of NMDA, the volume of neuron apoptosis damage caused by excitotoxicity is increased compared to in wild-type mice

cellular

increased susceptibility to neuronal excitotoxicity ( J:110616 )

• following injection of NMDA, the volume of neuron apoptosis damage caused by excitotoxicity is increased compared to in wild-type mice

Allelic Composition	Pdgfrb^tm2Msas/Pdgfrb^tm2Msas Tg(Nes-cre)1Nogu/?
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdgfrb^tm2Msas mutation (0 available); any Pdgfrb mutation (84 available)
Tg(Nes-cre)1Nogu mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal response to injury ( J:110616 )

• damage to the brain measured by TCC staining is increased following cryogenic injury

Allelic Composition	Npvf^tm1.1Ubu/Npvf^tm1.1Ubu Tg(Nes-cre)1Nogu/0
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Npvf^tm1.1Ubu mutation (0 available); any Npvf mutation (5 available)
Tg(Nes-cre)1Nogu mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:347241 )

N	• mice show normal spatial working memory in the Y maze test

decreased anxiety-related response ( J:347241 )

• mice spend shorter time in the closed arms of the elevated plus maze test and the number of closed arms entries tends to be decreased while time spent in the open arms is longer and number of open arms entries tends to be increased

hyperactivity ( J:347241 )

• mice perform more intensive exercise after light-off than wild-type mice and this high activity continues for 6 hours (ZT12-18)

hypoactivity ( J:347241 )

• activity tends to be significantly lower during most of the other hours (ZT0-12, 21-24)

• mice show reduced number of arm entries in the Y-maze

increased thermal nociceptive threshold ( J:347241 )

• latency to hindleg licking and jump, but not for foreleg licking, is longer in the hot plate test, indicating reduced sensitivity to pain

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