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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nus1+
wild type
MGI:3715650
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Nus1tm1.2Qrm/Nus1+ involves: 129P2/OlaHsd * FVB/N MGI:6361028
cn2
 		Nus1tm1Wcsa/Nus1+
Rtn4tm1Matl/Rtn4tm1Matl
Tg(Cdh5-cre/ERT2)1Rha/0 		involves: 129S7/SvEvBrd MGI:6361104


Genotype
MGI:6361028
ht1
Allelic
Composition		 Nus1tm1.2Qrm/Nus1+
Genetic
Background		 involves: 129P2/OlaHsd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nus1tm1.2Qrm mutation (0 available); any Nus1 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal vascular development ( J:229464 )
• embryoid bodies derived from embryonic stem cells exhibit defective blood vessel development, form dilated and truncated EC tubes which have less branching and fail to develop into a tree-like structure in vitro
• however, heterozygous mice are viable




Genotype
MGI:6361104
cn2
Allelic
Composition		 Nus1tm1Wcsa/Nus1+
Rtn4tm1Matl/Rtn4tm1Matl
Tg(Cdh5-cre/ERT2)1Rha/0
Genetic
Background		 involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nus1tm1Wcsa mutation (0 available); any Nus1 mutation (18 available)
Rtn4tm1Matl mutation (1 available); any Rtn4 mutation (130 available)
Tg(Cdh5-cre/ERT2)1Rha mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:230506 )
N
• embryos from tamoxifen-treated pregnant females at E8.5 do not show vascular defects




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/30/2025
MGI 6.24 		The Jackson Laboratory