Analysis Tools
cellular
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• mouse embryonic fibroblasts exposed to TAT-cre exhibit cell death unlike cells not exposed to TAT-cre
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mouse embryonic fibroblasts exposed to TAT-cre exhibit cell death unlike cells not exposed to TAT-cre
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice treated with tamoxifen exhibit a dosage and frequency dependent lethality dieing by 16 months unlike in mice lacking cre expression
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• all mice develop tumors in the juxta-articular region in the limbs with some evidence of calcification
• following tamoxifen treatment, all mice develop tumors in the juxta-articular region in the limbs with some evidence of calcification
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• mice develop synovial sarcomas
• following tamoxifen treatment, mice develop synovial sarcomas
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| synovial sarcoma | DOID:5485 |
OMIM:300813 |
J:147728 | |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• no embryos are recovered at E13.5 but are present at E10.5
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• no pups were recovered
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• at E8.5, embryonic tissue is highly disorganized
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• about 8% of mice die by 2 months of age
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• at 3 to 5 months, 18 of 18 surviving mice developed multiple tumors (3 to 5 per mouse) compared to over 100 control mice who did not develop tumors at more than 1 year of age
• however, mice that died prior to 2 months of age did not have tumors and did not die from tumor-related causes
• small and potentially metastatic tumors are detected
• most tumors are located within the skeletal muscle in the limbs and intercostals regions with some non-skeletal muscle tissues (such as the cerebellum) harboring tumors
• tumors are vascularized, hemorrhagic and cystic spaces are detected in large tumors
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• synovial sarcomas are detected with monophasic (13) outnumbering biphasic (3)
• myxoid and fibrous changes are observed
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• myf5+ lineage cells undergo increased apoptosis ate E11.5 and by E15.5 are absent
• however, myf5+ cells near future rib cartilage and skeletal musculogenesis are normal
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• about 8% of mice are born small
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| synovial sarcoma | DOID:5485 |
OMIM:300813 |
J:120967 | |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice die by 6 months of age
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| N |
• unlike in other Gt(ROSA)26Sortm3(SS18)Mrc homozygously activated mice, no tumors form
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• no pups are born but they can be recovered at E15.5
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• Pax7+ lineage cells are mostly absent except in the proximity to cartilaginous regions of the developing maxilla and nasal turbinates
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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