Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcgr3tm1Jsv mutation
(5 available);
any
Fcgr3 mutation
(29 available)
Sle21129P2/Ola mutation
(0 available);
any
Sle21 mutation
(0 available)
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mortality/aging
N |
• mice exhibit normal mortality
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immune system
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• increased activated B cell
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hematopoietic system
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• increased activated B cell
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growth/size/body
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcgr2btm1Ttk mutation
(7 available);
any
Fcgr2b mutation
(49 available)
Sle21129P2/Ola mutation
(0 available);
any
Sle21 mutation
(0 available)
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mortality/aging
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• at 8 and 12 months, mice develop fatal glomerular damage unlike wild-type mice
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immune system
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• mice exhibit increased antibody response after immunization, in mast cell-mediated cutaneous anaphylaxis, and in phagocytosis of immune complex (IC) by macrophages compared with control mice
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• kidney IgG and C3 depositions in a nephrotoxic nephritis model
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• in a nephrotoxic nephritis model that is more severe than in Fcgr2btm1.2Sjv homozygotes
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• collagen or K/BXN serum-induced that is more severe than in Fcgr2btm1.2Sjv homozygotes
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• spontaneous increase in Coombs, chromatin, double-strand DNA, single-strand DNA and histone autoantibodies
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• in a nephrotoxic nephritis model that is more severe than in Fcgr2btm1.2Sjv homozygotes
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renal/urinary system
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• in a nephrotoxic nephritis model
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• in a nephrotoxic nephritis model that is more severe than in Fcgr2btm1.2Sjv homozygotes
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• at 8 and 12 months, mice develop fatal glomerular damage unlike wild-type mice
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homeostasis/metabolism
skeleton
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• collagen or K/BXN serum-induced that is more severe than in Fcgr2btm1.2Sjv homozygotes
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hematopoietic system
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• kidney IgG and C3 depositions in a nephrotoxic nephritis model
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• in a nephrotoxic nephritis model that is more severe than in Fcgr2btm1.2Sjv homozygotes
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growth/size/body
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcgr2btm1.2Jsv mutation
(1 available);
any
Fcgr2b mutation
(49 available)
Fcgr2btm1Ttk mutation
(7 available);
any
Fcgr2b mutation
(49 available)
Sle21129P2/Ola mutation
(0 available);
any
Sle21 mutation
(0 available)
Sle21C57BL/6 mutation
(0 available);
any
Sle21 mutation
(0 available)
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mortality/aging
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• mice exhibit greater cumulative death compared with wild-type C57BL/6 mice
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immune system
renal/urinary system
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• kidney pathology is increased compared to in wild-type C57BL/6 mice
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homeostasis/metabolism
hematopoietic system
growth/size/body
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
C1qatm1Mjw mutation
(1 available);
any
C1qa mutation
(22 available)
Sle21129P2/Ola mutation
(0 available);
any
Sle21 mutation
(0 available)
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
C1qatm1Mjw mutation
(1 available);
any
C1qa mutation
(22 available)
Sle21129P2/Ola mutation
(0 available);
any
Sle21 mutation
(0 available)
Sle21C57BL/6 mutation
(0 available);
any
Sle21 mutation
(0 available)
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
C1qatm1Mjw mutation
(1 available);
any
C1qa mutation
(22 available)
Sle18C57BL/6 mutation
(0 available);
any
Sle18 mutation
(0 available)
Sle21129P2/Ola mutation
(0 available);
any
Sle21 mutation
(0 available)
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