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| Nomenclature |
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Symbol:
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Fcgr2btm1Ttk
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Name:
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Fc receptor, IgG, low affinity IIb;
targeted mutation 1, Toshiyuki Takai
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MGI ID: |
MGI:1857166 |
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Synonyms: |
FcgammaRII, FcgammaRII-, FcgammaRII2B-, FcgammaRIIb-, FcgammaRIIB-, Fcgr2btm1Rav, FcgRIIB129-, FcRIIB-, IIB- |
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Gene:
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Fcgr2b
Location:
Chr1:170960558-170976547 bp, - strand
Genetic Position: Chr1,
78.02 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:31133
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Parent Cell Line:
| J1 (ES Cell) |
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Strain of Origin:
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129S4/SvJae
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A 2.3 kb genomic fragment containing the S1 and EC1 exons was replaced by a neomycin resistance cassette. Encoded transcript was undetectable in homozygous mutant mice via Northern blot analysis (data not shown). Western blot analysis of LPS-stimulated B cells derived from homozygous mice confirmed that no protein was made from this allele, and FACS analysis demonstrated that no functional protein was expressed on the cell surface of B cells in homozygous mice. (J:31133)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:31133
Takai T et al.,
"Augmented humoral and anaphylactic responses in Fc gamma RII-deficient mice."
Nature 1996 Jan 25;379(6563):346-9
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All: |
168 reference(s)
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Analysis Tools
