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Fcgr3tm1Jsv
Targeted Allele Detail
Summary
Symbol: Fcgr3tm1Jsv
Name: Fc receptor, IgG, low affinity III; targeted mutation 1, J Sjef Verbeek
MGI ID: MGI:1861924
Synonyms: FcgammaRIII-, Fcgr3tm1Sjv
Gene: Fcgr3  Location: Chr1:170878743-170892504 bp, - strand  Genetic Position: Chr1, 78.8 cM
Alliance: Fcgr3tm1Jsv page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:35057
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA hygromycin selection cassette replaced a genomic fragment containing sequences encoding the ligand binding and part of the transmembrane domains. RT-PCR analysis on NK fractions of splenocytes derived from homozygous mice demonstrated that no detectable transcript was produced from this allele. Flow cytometry analysis on NK cells, B lymphocytes, macrophages and neutrophils confirmed that no detectable cell surface protein was encoded by this allele. (J:35057)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 5 strains available      Cell Lines: 0 lines available
Carrying any Fcgr3 Mutation:  21 strains or lines available
References
Original:  J:35057 Hazenbos WL, et al., Impaired IgG-dependent anaphylaxis and Arthus reaction in Fc gamma RIII (CD16) deficient mice. Immunity. 1996 Aug;5(2):181-8
All:  118 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/24/2023
MGI 6.22
The Jackson Laboratory