Analysis Tools
normal phenotype
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• mice are viable, fertile and normal in appearance
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Allele Symbol Allele Name Allele ID |
Furintm1Jwmc targeted mutation 1, John W M Creemers MGI:3700008 |
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| Summary |
5 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice are viable, fertile and normal in appearance
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• conditional mice show no liver phenotype
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• loss of connexin 37 staining at the surface of oocytes indicates impaired gap junctions between oocytes and surrounding granulosa cells at the early secondary follicle stage
• metaphase II (MII) oocytes collected after superovulation exhibit poor quality with degenerated first polar bodies and severely abnormal spindles
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• metaphase II (MII) oocytes collected after superovulation exhibit degenerated first polar bodies
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• at P35, TUNEL analysis showed severe apoptosis of granulosa cells in late preantral follicles and antral follicles
• however, no apparent apoptosis is detected in early secondary follicles
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• PCNA staining showed a severe defect in granulosa cell proliferation at 2 months of age
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• at 6 and 8 weeks of age, number of early secondary follicles is significantly increased while the number of large growing (late preantral) follicles is markedly decreased
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• number of antral follicles is markedly decreased
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• large antral follicles exhibit degeneration at 8 weeks of age; few or almost no late growing follicles or antral follicles are observed, suggesting atresia of follicles beyond the early secondary stage
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• at 6 weeks of age, the number of early secondary follicles is significantly increased while the number of large growing (late preantral) follicles and antral follicles is markedly decreased, indicating that primary follicles fail to develop beyond the early secondary follicle stage
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• ovaries are smaller at P42
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• metaphase II (MII) oocytes collected after superovulation exhibit severely abnormal spindles
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• following induction of ovulation with exogenous PMSG + hCG, the number of ovulated oocytes per 6-wk-old female is significantly lower than that in control females
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• females fail to ovulate during a natural ovulation assay
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• 8-wk-old or older females cannot be induced to ovulate anymore
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• when mated with fertile males for 6 months, females fail to produce any progeny indicating complete female infertility
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• loss of connexin 37 staining at the surface of oocytes indicates impaired gap junctions between oocytes and surrounding granulosa cells at the early secondary follicle stage
• metaphase II (MII) oocytes collected after superovulation exhibit poor quality with degenerated first polar bodies and severely abnormal spindles
|
|
|
• metaphase II (MII) oocytes collected after superovulation exhibit degenerated first polar bodies
|
|
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• at P35, TUNEL analysis showed severe apoptosis of granulosa cells in late preantral follicles and antral follicles
• however, no apparent apoptosis is detected in early secondary follicles
|
|
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• PCNA staining showed a severe defect in granulosa cell proliferation at 2 months of age
|
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• at P35, TUNEL analysis showed severe apoptosis of granulosa cells in late preantral follicles and antral follicles
• however, no apparent apoptosis is detected in early secondary follicles
|
|
|
• PCNA staining showed a severe defect in granulosa cell proliferation at 2 months of age
|
|
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• at 6 and 8 weeks of age, number of early secondary follicles is significantly increased while the number of large growing (late preantral) follicles is markedly decreased
|
|
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• number of antral follicles is markedly decreased
|
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• large antral follicles exhibit degeneration at 8 weeks of age; few or almost no late growing follicles or antral follicles are observed, suggesting atresia of follicles beyond the early secondary stage
|
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• at 6 weeks of age, the number of early secondary follicles is significantly increased while the number of large growing (late preantral) follicles and antral follicles is markedly decreased, indicating that primary follicles fail to develop beyond the early secondary follicle stage
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• ovaries are smaller at P42
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• PCNA staining showed a severe defect in granulosa cell proliferation at 2 months of age
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• number of early secondary follicles is significantly increased at 6 weeks of age
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• ovarian follicle development is arrested at the early secondary follicle stage
• however, number of primordial follicles is normal at 2 months of age, suggesting that survival and activation of primordial follicles is unaffected
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• PCNA staining showed a severe defect in granulosa cell proliferation at 2 months of age
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• PCNA staining showed a severe defect in granulosa cell proliferation at 2 months of age
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• number of early secondary follicles is significantly increased at 6 weeks of age
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• ovarian follicle development is arrested at the early secondary follicle stage
• however, number of primordial follicles is normal at 2 months of age, suggesting that survival and activation of primordial follicles is unaffected
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• regulatory T cells fail to drive Th17 differentiation
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• regulatory T cells fail to drive Th17 differentiation
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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