Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gfi1tm1Wep mutation
(0 available);
any
Gfi1 mutation
(31 available)
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growth/size/body
hematopoietic system
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• cultured cells transfected with a retroviral cre show reduced expansion in Il2 by 3-fold over 2 days following antiCD3/CD28 priming
• after 2 days, in cre-transfected cultured cells, Il4-producing cells are decreased by ~13% compared to GFP transfected controls
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• have elevated population of Cd11b+ cells in spleen; this group was excluded from further studies and only 'healthy' animals were studied further
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immune system
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• cultured cells transfected with a retroviral cre show reduced expansion in Il2 by 3-fold over 2 days following antiCD3/CD28 priming
• after 2 days, in cre-transfected cultured cells, Il4-producing cells are decreased by ~13% compared to GFP transfected controls
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cellular
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• cultured cells transfected with a retroviral cre show reduced expansion in Il2 by 3-fold over 2 days following antiCD3/CD28 priming
• after 2 days, in cre-transfected cultured cells, Il4-producing cells are decreased by ~13% compared to GFP transfected controls
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gfi1btm2Tmo mutation
(0 available);
any
Gfi1b mutation
(20 available)
Gfi1tm1Wep mutation
(0 available);
any
Gfi1 mutation
(31 available)
Tg(Mx1-cre)1Cgn mutation
(7 available)
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hematopoietic system
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• numbers drastically reduced 15 days after the first pIpC injection to induce cre expression
• numbers restored by 40 days
• Gfi1b excision is incomplete
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gfi1tm1Wep mutation
(0 available);
any
Gfi1 mutation
(31 available)
Tg(Cd4-cre)1Cwi mutation
(10 available)
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hematopoietic system
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• after 3-day priming iunder Th2 conditions and restimulation for 4 hours, an ~19% decrease in percentage of Il4-producing cells is seen compared to controls
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• ratio of CD4 single positive to CD8 single positive thymocytes is slightly reduced
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• after infection with Schistosoma mansonii, 6-8 weeks later fewer lymph node cells make Il4 compared to controls
• after schistosoma egg antigen (SEA) stimulation for 5 days, ~3-fold fewer cells make Il4; production of other Th2 cytokines is reduced ~3-fold compared to control levels
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immune system
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• after 3-day priming iunder Th2 conditions and restimulation for 4 hours, an ~19% decrease in percentage of Il4-producing cells is seen compared to controls
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• ratio of CD4 single positive to CD8 single positive thymocytes is slightly reduced
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• after infection with Schistosoma mansonii, 6-8 weeks later fewer lymph node cells make Il4 compared to controls
• after schistosoma egg antigen (SEA) stimulation for 5 days, ~3-fold fewer cells make Il4; production of other Th2 cytokines is reduced ~3-fold compared to control levels
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cellular
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• after 3-day priming iunder Th2 conditions and restimulation for 4 hours, an ~19% decrease in percentage of Il4-producing cells is seen compared to controls
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Analysis Tools