All Phenotypes Abcg1<tm1Dgen> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Abcg1^tm1Dgen/Abcg1^tm1Dgen	B6.129P2-Abcg1^tm1Dgen	MGI:3695600
hm2	Abcg1^tm1Dgen/Abcg1^tm1Dgen	involves: 129P2/OlaHsd	MGI:4940640
hm3	Abcg1^tm1Dgen/Abcg1^tm1Dgen	involves: 129P2/OlaHsd * C57BL/6	MGI:3796559
cx4	Abcg1^tm1Dgen/Abcg1⁺ Abcg4^tm1Dgen/Abcg4^tm1Dgen	involves: 129P2/OlaHsd	MGI:4940635
cx5	Abcg1^tm1Dgen/Abcg1^tm1Dgen Abcg4^tm1Dgen/Abcg4^tm1Dgen	involves: 129P2/OlaHsd	MGI:4940638
cx6	Abcg1^tm1Dgen/Abcg1^tm1Dgen Abcg4^tm1Dgen/Abcg4⁺	involves: 129P2/OlaHsd	MGI:4940639
cx7	Abca1^tm1Jdm/Abca1^tm1Jdm Abcg1^tm1Dgen/Abcg1^tm1Dgen	involves: 129P2/OlaHsd * C57BL/6 * DBA/1LacJ	MGI:3796569
cx8	Abca1^tm1Jdm/Abca1^tm1Jdm Abcg1^tm1Dgen/Abcg1^tm1Dgen Apoe^tm1Unc/Apoe^tm1Unc	involves: 129P2/OlaHsd * C57BL/6 * DBA * DBA/1LacJ	MGI:5451015
cx9	Abca1^tm1Jdm/Abca1^tm1Jdm Abcg1^tm1Dgen/Abcg1^tm1Dgen Tg(APOA1)1Rub/0	involves: 129P2/OlaHsd * C57BL/6 * DBA * DBA/1LacJ	MGI:5451014
cx10	Abca1^tm1Jdm/Abca1^tm1Jdm Abcg1^tm1Dgen/Abcg1^tm1Dgen	involves: 129P2/OlaHsd * C57BL/6 * DBA * DBA/1LacJ	MGI:5451013

Allelic Composition	Abcg1^tm1Dgen/Abcg1^tm1Dgen
Genetic Background	B6.129P2-Abcg1^tm1Dgen

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abcg1^tm1Dgen mutation (0 available); any Abcg1 mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

liver/biliary system

hepatic steatosis ( J:117028 )

• lipid accumulation is greater in mutant livers than in controls

respiratory system

abnormal lung morphology ( J:117028 )

• on a high fat/high cholesterol diet for 9 weeks, lungs exhibit irregular surfaces containing large crevices: on regular chow diet, lungs of mutants >15 weeks of age show presence of lipids

• pale foci indicative of lipid accumulation are visible

• chow-fed mice have giant cells, multiple lymphocytes and lipid positive macrophages in the lungs at 6 months of age

• subpleural region shows massive neutral lipid accumulation, and presence of many cholesterol clefts, multinucleated giant cells, and lymphocytes

homeostasis/metabolism

increased cholesterol level ( J:117028 )

• significantly increased in liver and lungs of mutants on high fat/high cholesterol diet, compared to wild-type controls

abnormal phospholipid level ( J:117028 )

• phospholipid levels are significantly increased in liver and lungs of mutants on high fat/high cholesterol diet, compared to wild-type controls

increased triglyceride level ( J:117028 )

• significantly increased in liver and lungs of mutants on high fat/high cholesterol diet, compared to wild-type controls

immune system

increased macrophage derived foam cell number ( J:117028 )

• macrophage foam cells are present in subpleural region, containing lipid droplets and cholesterol clefts

abnormal macrophage physiology ( J:117028 )

• macrophage foam cells contain lipid droplets and many cholesterol clefts, suggesting defects in normal cholesterol processing; some macrophages also contain pneumocyte type II alveolar cells

• efflux of cholesterol to endogenous lipid receptors like HDL an apoA1 is impaired when macrophages are treated with LXR/RXR ligands

renal/urinary system

renal/urinary system phenotype ( J:117028 )

N	• kidneys of mutants do not show lipid accumulation, glomerulonephritis, or inflammatory cell infiltration

hematopoietic system

increased macrophage derived foam cell number ( J:117028 )

• macrophage foam cells are present in subpleural region, containing lipid droplets and cholesterol clefts

abnormal macrophage physiology ( J:117028 )

• macrophage foam cells contain lipid droplets and many cholesterol clefts, suggesting defects in normal cholesterol processing; some macrophages also contain pneumocyte type II alveolar cells

• efflux of cholesterol to endogenous lipid receptors like HDL an apoA1 is impaired when macrophages are treated with LXR/RXR ligands

cellular

increased macrophage derived foam cell number ( J:117028 )

• macrophage foam cells are present in subpleural region, containing lipid droplets and cholesterol clefts

Allelic Composition	Abcg1^tm1Dgen/Abcg1^tm1Dgen
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abcg1^tm1Dgen mutation (0 available); any Abcg1 mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal lipid level ( J:141549 )

• mice exhibit a 1.4-fold increase in brain desmosterol levels compared with wild-type mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal leukocyte morphology ( J:132952 )

abnormal monocyte differentiation ( J:132952 )

• monocyte recruitment and differentiation in the lungs is increased compared to in wild-type mice

increased eosinophil cell number ( J:132952 )

• 12-fold in the lungs at 7 weeks

increased neutrophil cell number ( J:132952 )

• the number of circulating monocytes is 2-fold higher than in wild-type mice

increased dendritic cell number ( J:132952 )

• 2.6-fold in the lungs at 7 weeks

increased B cell number ( J:132952 )

• 1.7-fold in the lungs at 7 weeks

increased CD4-positive, alpha-beta T cell number ( J:132952 )

• 1.7-fold in the lungs at 7 weeks

increased CD8-positive, alpha-beta T cell number ( J:132952 )

• 1.3-fold in the lungs at 7 weeks

increased monocyte cell number ( J:132952 )

• the number of circulating monocytes is 2-fold higher than in wild-type mice

abnormal macrophage morphology ( J:132952 )

• at 7 weeks, macrophages in the lungs are larger in size than wild-type and exhibit severe lipid accumulation unlike in wild-type lungs

abnormal cytokine secretion ( J:130777 )

• mice exhibit increased secretion of TNF-alpha, IL-1beta, and IL-12 compared to wild-type mice

abnormal chemokine secretion ( J:130777 )

• mice exhibit increased secretion of MIP-1alpha, MIP-2 and MCP-1 compared to wild-type mice

lung inflammation ( J:132952 )

• at 7 weeks, mice exhibit increased cytokine levels in bronchialveolar lavage fluid (BAL)

• alveolar macrophage cell supernatant contains increased levels of IL-6, IL-1beta, IL-1alpha, IL-12 and KC with decreased levels of IL-10

• however, alveolar macrophage cell numbers, and plasma levels of chemokine other than KC and cytokine are normal

• BAL fluid exhibits increased numbers of CD8+ and CD4+ T cells, B cells, eosinophils, neutrophils and dendritic cells compared to in wild-type BAL fluid

• reconstitution of mice with wild-type bone marrow increased macrophage accumulation but decrease neutrophil, dendritic cell, and eosinophil accumulation while reconstitution wild-type mice with mutant bone marrow decreased macrophage accumulation but increased neutrophil, dendritic cells and eosinophil accumulation

respiratory system

lung inflammation ( J:132952 )

• at 7 weeks, mice exhibit increased cytokine levels in bronchialveolar lavage fluid (BAL)

• alveolar macrophage cell supernatant contains increased levels of IL-6, IL-1beta, IL-1alpha, IL-12 and KC with decreased levels of IL-10

• however, alveolar macrophage cell numbers, and plasma levels of chemokine other than KC and cytokine are normal

• BAL fluid exhibits increased numbers of CD8+ and CD4+ T cells, B cells, eosinophils, neutrophils and dendritic cells compared to in wild-type BAL fluid

abnormal lung morphology ( J:132952 )

• at 3 weeks of age mice exhibit an accumulation of lipids at the edge of the lung lobe and by 8 months exhibit a severe accumulation of lipid in all parts of the lung unlike wild-type mice

overexpanded pulmonary alveolus ( J:132952 )

• at 8 months, mice exhibit enlargement of the alveoli unlike in wild-type mice

abnormal surfactant secretion ( J:132952 )

• at 7 weeks of age mice exhibit an increase in surfactant D in the lungs

homeostasis/metabolism

decreased cholesterol efflux ( J:130777 )

lipidosis ( J:132952 )

• at 3 weeks of age mice exhibit an accumulation of lipids at the edge of the lung lobe and by 8 months exhibit a severe accumulation of lipid in all parts of the lung unlike wild-type mice

cellular

abnormal monocyte differentiation ( J:132952 )

• monocyte recruitment and differentiation in the lungs is increased compared to in wild-type mice

decreased cholesterol efflux ( J:130777 )

hematopoietic system

abnormal leukocyte morphology ( J:132952 )

abnormal monocyte differentiation ( J:132952 )

• monocyte recruitment and differentiation in the lungs is increased compared to in wild-type mice

increased eosinophil cell number ( J:132952 )

• 12-fold in the lungs at 7 weeks

increased neutrophil cell number ( J:132952 )

• the number of circulating monocytes is 2-fold higher than in wild-type mice

increased dendritic cell number ( J:132952 )

• 2.6-fold in the lungs at 7 weeks

increased B cell number ( J:132952 )

• 1.7-fold in the lungs at 7 weeks

increased CD4-positive, alpha-beta T cell number ( J:132952 )

• 1.7-fold in the lungs at 7 weeks

increased CD8-positive, alpha-beta T cell number ( J:132952 )

• 1.3-fold in the lungs at 7 weeks

increased monocyte cell number ( J:132952 )

• the number of circulating monocytes is 2-fold higher than in wild-type mice

abnormal macrophage morphology ( J:132952 )

• at 7 weeks, macrophages in the lungs are larger in size than wild-type and exhibit severe lipid accumulation unlike in wild-type lungs

Allelic Composition	Abcg1^tm1Dgen/Abcg1⁺ Abcg4^tm1Dgen/Abcg4^tm1Dgen
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abcg1^tm1Dgen mutation (0 available); any Abcg1 mutation (45 available)
Abcg4^tm1Dgen mutation (0 available); any Abcg4 mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased cholesterol efflux ( J:141549 )

• astrocytes exhibit a moderate increase in cholesterol mass compared with wild-type cells

• astrocyte cholesterol efflux is decreased compared to in wild-type cells

abnormal lipid homeostasis ( J:141549 )

• astrocytes exhibit decreased sterol synthesis compared with wild-type cells

• astrocyte desmosterol efflux is decreased compared to in wild-type cells

• astrocyte HDL-dependent desmosterol efflux is decreased compared to in wild-type cells

abnormal lipid level ( J:141549 )

• desmosterol levels are increased 2-fold in astrocytes compared to in wild-type cells

cellular

decreased cholesterol efflux ( J:141549 )

• astrocytes exhibit a moderate increase in cholesterol mass compared with wild-type cells

• astrocyte cholesterol efflux is decreased compared to in wild-type cells

Allelic Composition	Abcg1^tm1Dgen/Abcg1^tm1Dgen Abcg4^tm1Dgen/Abcg4^tm1Dgen
Genetic Background	involves: 129P2/OlaHsd

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased cholesterol efflux ( J:141549 )

• astrocytes exhibit a moderate increase in cholesterol mass compared with wild-type cells

• astrocyte cholesterol efflux is decreased compared to in wild-type cells

• HDL-dependent cholesterol efflux in astrocytes is decreased compared to in wild-type cells

abnormal lipid homeostasis ( J:141549 )

• astrocytes exhibit decreased sterol synthesis compared with wild-type cells

• astrocyte desmosterol efflux is decreased compared to in wild-type cells

• astrocyte HDL-dependent desmosterol efflux is decreased compared to in wild-type cells

abnormal cholesterol homeostasis ( J:141549 )

• cholesterol tracer transfer from astrocytes to neurons is decreased compared to in wild-type cells

abnormal lipid level ( J:141549 )

• mice exhibit a 2.4-fold increase in brain desmosterol levels compared with wild-type mice

• brain lanosterol, lathosterol, and 27-OH-cholesterol levels are increased by 1.9-, 1.5-, and 1.7-fold, respectively, compared with wild-type mice

• however, mice exhibit normal levels of brain cholesterol, 24(S)-OH-cholesterol, and plant sterol levels

• desmosterol levels are increased 4-fold in astrocytes compared to in wild-type cells

cellular

decreased cholesterol efflux ( J:141549 )

• astrocytes exhibit a moderate increase in cholesterol mass compared with wild-type cells

• astrocyte cholesterol efflux is decreased compared to in wild-type cells

• HDL-dependent cholesterol efflux in astrocytes is decreased compared to in wild-type cells

Allelic Composition	Abcg1^tm1Dgen/Abcg1^tm1Dgen Abcg4^tm1Dgen/Abcg4⁺
Genetic Background	involves: 129P2/OlaHsd

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased cholesterol efflux ( J:141549 )

• astrocytes exhibit a moderate increase in cholesterol mass compared with wild-type cells

• astrocyte cholesterol efflux is decreased compared to in wild-type cells

abnormal lipid homeostasis ( J:141549 )

• astrocytes exhibit decreased sterol synthesis compared with wild-type cells

• astrocyte desmosterol efflux is decreased compared to in wild-type cells

• astrocyte HDL-dependent desmosterol efflux is decreased compared to in wild-type cells

abnormal lipid level ( J:141549 )

• desmosterol levels are increased 2-fold in astrocytes compared to in wild-type cells

cellular

decreased cholesterol efflux ( J:141549 )

• astrocytes exhibit a moderate increase in cholesterol mass compared with wild-type cells

• astrocyte cholesterol efflux is decreased compared to in wild-type cells

Allelic Composition	Abca1^tm1Jdm/Abca1^tm1Jdm Abcg1^tm1Dgen/Abcg1^tm1Dgen
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * DBA/1LacJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abca1^tm1Jdm mutation (1 available); any Abca1 mutation (88 available)
Abcg1^tm1Dgen mutation (0 available); any Abcg1 mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal cytokine secretion ( J:130777 )

• mice exhibit increased secretion of TNF-alpha, IL-6, IL-1beta, and IL-12 compared to wild-type mice

abnormal chemokine secretion ( J:130777 )

• mice exhibit increased secretion of MIP-1alpha, MIP-2, growth-regulated oncogene alpha and MCP-1 compared to wild-type mice

cellular

decreased cholesterol efflux ( J:130777 )

homeostasis/metabolism

decreased cholesterol efflux ( J:130777 )

Allelic Composition	Abca1^tm1Jdm/Abca1^tm1Jdm Abcg1^tm1Dgen/Abcg1^tm1Dgen Apoe^tm1Unc/Apoe^tm1Unc
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * DBA * DBA/1LacJ

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal hematopoietic system physiology ( J:190966 )

• mice fed a high fat diet exhibit increased hematopoietic stem and multipotential progenitor cell (HSPC) mobilization compared with wild-type mice

• however, treatment with recombinant HDL suppresses this increase

Allelic Composition	Abca1^tm1Jdm/Abca1^tm1Jdm Abcg1^tm1Dgen/Abcg1^tm1Dgen Tg(APOA1)1Rub/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * DBA * DBA/1LacJ

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal hematopoietic system physiology ( J:190966 )

• in bone marrow transplants experiments, hematopoietic stem and multipotential progenitor cell (HSPC) exhibit reduced mobilization compared with Abca1^tm1Jdm Abcg1^tm1Dgen double homozygotes

Allelic Composition	Abca1^tm1Jdm/Abca1^tm1Jdm Abcg1^tm1Dgen/Abcg1^tm1Dgen
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * DBA * DBA/1LacJ

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

extramedullary hematopoiesis ( J:190966 )

abnormal bone marrow cell morphology/development ( J:190966 )

• mice exhibit a decrease in heterogeneous distribution of bone tissue material properties compared with wild-type mice

abnormal common myeloid progenitor cell morphology ( J:190966 )

• increased 3-fold

increased neutrophil cell number ( J:190966 )

• from in vitro bone marrow cultures treated with G-CSF or IL3

decreased monocyte cell number ( J:190966 )

• from in vitro bone marrow cultures treated with G-CSF

increased monocyte cell number ( J:190966 )

• from in vitro bone marrow cultures treated with IL3

increased hematopoietic stem cell number ( J:190966 )

abnormal hematopoietic system physiology ( J:190966 )

• hematopoietic stem and multipotential progenitor cell (HSPC) mobilization is enhanced that is bone marrow- and G-CSF-dependent driven by increased IL23/IL17

skeleton

abnormal bone structure ( J:190966 )

immune system

increased neutrophil cell number ( J:190966 )

• from in vitro bone marrow cultures treated with G-CSF or IL3

decreased monocyte cell number ( J:190966 )

• from in vitro bone marrow cultures treated with G-CSF

increased monocyte cell number ( J:190966 )

• from in vitro bone marrow cultures treated with IL3

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