About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ephb2tm1Jf
targeted mutation 1, Jonas Frisen
MGI:3692752
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ephb2tm1Jf/Ephb2tm1Jf involves: 129S1/Sv * 129X1/SvJ MGI:3697240
hm2
Ephb2tm1Jf/Ephb2tm1Jf involves: 129S1/Sv * 129X1/SvJ * CD-1 MGI:4431261
ht3
Ephb2tm1Jf/Ephb2+ involves: 129S1/Sv * 129X1/SvJ MGI:3697241
cx4
Ephb2tm1Jf/Ephb2tm1Jf
Lnx1tm1Henk/Lnx1tm1Henk
involves: 129S1/Sv * 129X1/SvJ * CD-1 MGI:8228079
cx5
Efnb3tm1.1Henk/Efnb3tm1.1Henk
Ephb2tm1Jf/Ephb2tm1Jf
Lnx1tm1Henk/Lnx1tm1Henk
involves: 129S1/Sv * 129X1/SvJ * CD-1 MGI:8228084


Genotype
MGI:3697240
hm1
Allelic
Composition
Ephb2tm1Jf/Ephb2tm1Jf
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ephb2tm1Jf mutation (0 available); any Ephb2 mutation (68 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
• a 19% and 30% increase in the number of proliferating cells is detected in crypts in the small intestine and colon, respectively
• however, no signs of cell migration defects are seen in the intestinal epithelium

endocrine/exocrine glands
• a 19% and 30% increase in the number of proliferating cells is detected in crypts in the small intestine and colon, respectively
• however, no signs of cell migration defects are seen in the intestinal epithelium

nervous system
• some mice exhibit ventral-temporal (VT) retinal ganglion cell axon mapping defects compared with control mice




Genotype
MGI:4431261
hm2
Allelic
Composition
Ephb2tm1Jf/Ephb2tm1Jf
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ephb2tm1Jf mutation (0 available); any Ephb2 mutation (68 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
• cell proliferation is increased in the intestinal epithelium
• treatment with Gleevec (an Abl kinase inhibitor,imatinib mesylate) reduces proliferation of intestinal epithelial cells to a level indistinguishable from that in treated wild-type mice




Genotype
MGI:3697241
ht3
Allelic
Composition
Ephb2tm1Jf/Ephb2+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ephb2tm1Jf mutation (0 available); any Ephb2 mutation (68 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
• a 12% and 17% increase in the number of proliferating cells is detected in crypts in the small intestine and colon, respectively
• however, no signs of cell migration defects are seen in the intestinal epithelium

endocrine/exocrine glands
• a 12% and 17% increase in the number of proliferating cells is detected in crypts in the small intestine and colon, respectively
• however, no signs of cell migration defects are seen in the intestinal epithelium

nervous system
• some mice exhibit dorsal and ventral-temporal (VT) retinal ganglion cell axon mapping defects compared with control mice




Genotype
MGI:8228079
cx4
Allelic
Composition
Ephb2tm1Jf/Ephb2tm1Jf
Lnx1tm1Henk/Lnx1tm1Henk
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ephb2tm1Jf mutation (0 available); any Ephb2 mutation (68 available)
Lnx1tm1Henk mutation (0 available); any Lnx1 mutation (43 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• rescue of mossy fiber axon terminal targeting compared to mice null for Lnx1 alone
• paired-pulse ratio is also restored to normal levels




Genotype
MGI:8228084
cx5
Allelic
Composition
Efnb3tm1.1Henk/Efnb3tm1.1Henk
Ephb2tm1Jf/Ephb2tm1Jf
Lnx1tm1Henk/Lnx1tm1Henk
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Efnb3tm1.1Henk mutation (0 available); any Efnb3 mutation (11 available)
Ephb2tm1Jf mutation (0 available); any Ephb2 mutation (68 available)
Lnx1tm1Henk mutation (0 available); any Lnx1 mutation (43 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• disruption of mossy fiber axon terminal targeting





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
07/29/2025
MGI 6.24
The Jackson Laboratory