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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ephb2tm1Jf
targeted mutation 1, Jonas Frisen
MGI:3692752
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ephb2tm1Jf/Ephb2tm1Jf involves: 129S1/Sv * 129X1/SvJ MGI:3697240
hm2
 		Ephb2tm1Jf/Ephb2tm1Jf involves: 129S1/Sv * 129X1/SvJ * CD-1 MGI:4431261
ht3
 		Ephb2tm1Jf/Ephb2+ involves: 129S1/Sv * 129X1/SvJ MGI:3697241


Genotype
MGI:3697240
hm1
Allelic
Composition		 Ephb2tm1Jf/Ephb2tm1Jf
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ephb2tm1Jf mutation (0 available); any Ephb2 mutation (66 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
abnormal crypts of Lieberkuhn morphology ( J:115873 )
• a 19% and 30% increase in the number of proliferating cells is detected in crypts in the small intestine and colon, respectively
• however, no signs of cell migration defects are seen in the intestinal epithelium

endocrine/exocrine glands
abnormal crypts of Lieberkuhn morphology ( J:115873 )
• a 19% and 30% increase in the number of proliferating cells is detected in crypts in the small intestine and colon, respectively
• however, no signs of cell migration defects are seen in the intestinal epithelium

nervous system
abnormal axon morphology ( J:176056 )
• some mice exhibit ventral-temporal (VT) retinal ganglion cell axon mapping defects compared with control mice




Genotype
MGI:4431261
hm2
Allelic
Composition		 Ephb2tm1Jf/Ephb2tm1Jf
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ephb2tm1Jf mutation (0 available); any Ephb2 mutation (66 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
abnormal digestive system physiology ( J:157019 )
• cell proliferation is increased in the intestinal epithelium
• treatment with Gleevec (an Abl kinase inhibitor,imatinib mesylate) reduces proliferation of intestinal epithelial cells to a level indistinguishable from that in treated wild-type mice




Genotype
MGI:3697241
ht3
Allelic
Composition		 Ephb2tm1Jf/Ephb2+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ephb2tm1Jf mutation (0 available); any Ephb2 mutation (66 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
abnormal crypts of Lieberkuhn morphology ( J:115873 )
• a 12% and 17% increase in the number of proliferating cells is detected in crypts in the small intestine and colon, respectively
• however, no signs of cell migration defects are seen in the intestinal epithelium

endocrine/exocrine glands
abnormal crypts of Lieberkuhn morphology ( J:115873 )
• a 12% and 17% increase in the number of proliferating cells is detected in crypts in the small intestine and colon, respectively
• however, no signs of cell migration defects are seen in the intestinal epithelium

nervous system
abnormal axon morphology ( J:176056 )
• some mice exhibit dorsal and ventral-temporal (VT) retinal ganglion cell axon mapping defects compared with control mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory